SMYD4

SET and MYND domain-containing protein 4 is a protein that in humans is encoded by the SMYD4 gene.[5][6]

SMYD4
Identifiers
AliasesSMYD4, ZMYND21, SET and MYND domain containing 4
External IDsMGI: 2442796 HomoloGene: 35098 GeneCards: SMYD4
Orthologs
SpeciesHumanMouse
Entrez

114826

319822

Ensembl

ENSG00000186532

ENSMUSG00000018809

UniProt

Q8IYR2

Q8BTK5

RefSeq (mRNA)

NM_052928

NM_001102611
NM_177009

RefSeq (protein)

NP_443160

NP_001096081

Location (UCSC)Chr 17: 1.78 – 1.83 MbChr 11: 75.24 – 75.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of SMYD4 function. A conditional knockout mouse line, called Smyd4tm1a(EUCOMM)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty six tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000186532 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018809 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T; Kikuno R; Ohara O (Sep 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
  6. "Entrez Gene: SMYD4 SET and MYND domain containing 4".
  7. "Salmonella infection data for Smyd4". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Smyd4". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS; Rossant J; Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L; White JK; Adams DJ; Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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