NHP2L1

NHP2-like protein 1 is a protein that in humans is encoded by the SNU13 gene.[4][5]

SNU13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNU13, 15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1, NHP2L1, SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5), small nuclear ribonucleoprotein 13
External IDsOMIM: 601304 MGI: 893586 HomoloGene: 3672 GeneCards: SNU13
Orthologs
SpeciesHumanMouse
Entrez

4809

20826

Ensembl

ENSG00000100138

ENSMUSG00000063480

UniProt

P55769

Q9D0T1

RefSeq (mRNA)

NM_001003796
NM_005008

NM_011482

RefSeq (protein)

NP_001003796
NP_004999

NP_035612

Location (UCSC)Chr 22: 41.67 – 41.69 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.[5]

Interactions

SNU13 has been shown to interact with RAD17.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000100138 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y (Jan 1997). "Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2". Cytogenetics and Cell Genetics. 72 (2–3): 191–3. doi:10.1159/000134186. PMID 8978773.
  5. "Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)".
  6. Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". The Journal of Biological Chemistry. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953.

Further reading

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