SOSTDC1

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[5]

SOSTDC1
Identifiers
AliasesSOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDsOMIM: 609675 MGI: 1913292 HomoloGene: 9154 GeneCards: SOSTDC1
Orthologs
SpeciesHumanMouse
Entrez

25928

66042

Ensembl

ENSG00000171243

ENSMUSG00000036169

UniProt

Q6X4U4

Q9CQN4

RefSeq (mRNA)

NM_015464

NM_025312

RefSeq (protein)

NP_056279

NP_079588

Location (UCSC)Chr 7: 16.46 – 16.53 MbChr 12: 36.36 – 36.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000171243 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036169 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SOSTDC1 sclerostin domain containing 1".

Further reading


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