Sperm-associated antigen 8

Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.[5][6][7]

SPAG8
Identifiers
AliasesSPAG8, BS-84, CILD28, CT142, HSD-1, SMP1, SPAG3, hSMP-1, sperm associated antigen 8
External IDsOMIM: 605731 MGI: 3056295 HomoloGene: 8250 GeneCards: SPAG8
Orthologs
SpeciesHumanMouse
Entrez

26206

433700

Ensembl

ENSG00000137098

ENSMUSG00000066196

UniProt

Q99932

Q3V0Q6

RefSeq (mRNA)

NM_001039592
NM_012436
NM_172312

NM_001007463
NM_001290462

RefSeq (protein)

NP_001034681
NP_758516
NP_001353689

NP_001007464
NP_001277391

Location (UCSC)Chr 9: 35.81 – 35.81 MbChr 4: 43.65 – 43.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000137098 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000066196 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang H, Miao S, Chen D, Wang L, Koide SS (Nov 1999). "Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1)". Biochim Biophys Acta. 1447 (1): 119–24. doi:10.1016/s0167-4781(99)00136-0. PMID 10500252.
  6. Liu QY, Wang LF, Miao SY, Catterall JF (Oct 1996). "Expression and characterization of a novel human sperm membrane protein". Biol Reprod. 54 (2): 323–30. doi:10.1095/biolreprod54.2.323. PMID 8788182.
  7. "Entrez Gene: SPAG8 sperm associated antigen 8".

Further reading


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