SPINT2

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.[5][6][7] SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

SPINT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPINT2, DIAR3, HAI-2, HAI2, Kop, PB, serine peptidase inhibitor, Kunitz type, 2, serine peptidase inhibitor, Kunitz type 2
External IDsOMIM: 605124 MGI: 1338031 HomoloGene: 7955 GeneCards: SPINT2
Orthologs
SpeciesHumanMouse
Entrez

10653

20733

Ensembl

ENSG00000167642

ENSMUSG00000074227

UniProt

O43291

Q9WU03

RefSeq (mRNA)

NM_021102
NM_001166103

NM_001082548
NM_011464

RefSeq (protein)

NP_001159575
NP_066925

NP_001076017
NP_035594

Location (UCSC)Chr 19: 38.24 – 38.29 MbChr 7: 28.96 – 28.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000167642 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074227 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP (May 1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". The Journal of Biological Chemistry. 272 (18): 12202–8. doi:10.1074/jbc.272.18.12202. PMID 9115294.
  6. Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (Oct 1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890.
  7. "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O43291 (Kunitz-type protease inhibitor 2) at the PDBe-KB.


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