SPN1

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.[5][6]

SNUPN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNUPN, KPNBL, RNUT1, Snurportin1, snurportin 1
External IDsOMIM: 607902 MGI: 1913319 HomoloGene: 4166 GeneCards: SNUPN
Orthologs
SpeciesHumanMouse
Entrez

10073

66069

Ensembl

ENSG00000169371

ENSMUSG00000055334

UniProt

O95149

Q80W37

RefSeq (mRNA)

NM_005701
NM_001042581
NM_001042588

NM_178374

RefSeq (protein)

NP_001036046
NP_001036053
NP_005692

NP_848461

Location (UCSC)Chr 15: 75.6 – 75.63 MbChr 9: 56.86 – 56.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000169371 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055334 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure". EMBO J. 17 (14): 4114–26. doi:10.1093/emboj/17.14.4114. PMC 1170744. PMID 9670026.
  6. "Entrez Gene: SNUPN snurportin 1".

Further reading


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