SSX2IP

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene.[5] It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation.[6][7][8][9][10] The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.[11][12]

SSX2IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSSX2IP, ADIP, synovial sarcoma, X breakpoint 2 interacting protein, SSX family member 2 interacting protein, hMsd1
External IDsOMIM: 608690 MGI: 2139150 HomoloGene: 8522 GeneCards: SSX2IP
Orthologs
SpeciesHumanMouse
Entrez

117178

99167

Ensembl

ENSG00000117155

ENSMUSG00000036825

UniProt

Q9Y2D8

Q8VC66

RefSeq (mRNA)

NM_001166293
NM_001166294
NM_001166295
NM_001166417
NM_014021

NM_001253768
NM_001253769
NM_001253770
NM_138744
NM_001355661

RefSeq (protein)

NP_001159765
NP_001159766
NP_001159767
NP_001159889
NP_054740

NP_001240697
NP_001240698
NP_001240699
NP_620083
NP_001342590

Location (UCSC)Chr 1: 84.64 – 84.69 MbChr 3: 146.11 – 146.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

SSX2IP has been initially described as a protein to interact with MLLT4[13] and Actinin, alpha 1.[13] In the context of centrosome maturation and ciliogenesis it has been shown to interact with WDR8.[8][9][11]

References

  1. GRCh38: Ensembl release 89: ENSG00000117155 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036825 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SSX2IP synovial sarcoma, X breakpoint 2 interacting protein".
  6. Bärenz F, Inoue D, Yokoyama H, Tegha-Dunghu J, Freiss S, Draeger S, et al. (July 2013). "The centriolar satellite protein SSX2IP promotes centrosome maturation". The Journal of Cell Biology. 202 (1): 81–95. doi:10.1083/jcb.201302122. PMC 3704989. PMID 23816619.
  7. Yukawa M, Ikebe C, Toda T (May 2015). "The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies". The Journal of Cell Biology. 209 (4): 549–62. doi:10.1083/jcb.201412111. PMC 4442821. PMID 25987607.
  8. Inoue D, Stemmer M, Thumberger T, Ruppert T, Bärenz F, Wittbrodt J, Gruss OJ (January 2017). "Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses". Nature Communications. 8: 14090. Bibcode:2017NatCo...814090I. doi:10.1038/ncomms14090. PMC 5253655. PMID 28098238.
  9. Hori A, Morand A, Ikebe C, Frith D, Snijders AP, Toda T (2015-12-04). "The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation". Biochemical and Biophysical Research Communications. 468 (1–2): 39–45. doi:10.1016/j.bbrc.2015.10.169. PMC 4669408. PMID 26545777.
  10. Hori A, Peddie CJ, Collinson LM, Toda T (June 2015). "Centriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly". Molecular Biology of the Cell. 26 (11): 2005–19. doi:10.1091/mbc.E14-11-1561. PMC 4472012. PMID 25833712.
  11. Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G (February 2016). "WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis". Journal of Cell Science. 129 (3): 621–36. doi:10.1242/jcs.179713. PMID 26675238.
  12. Klinger M, Wang W, Kuhns S, Bärenz F, Dräger-Meurer S, Pereira G, Gruss OJ (February 2014). "The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone". Molecular Biology of the Cell. 25 (4): 495–507. doi:10.1091/mbc.E13-09-0526. PMC 3923641. PMID 24356449.
  13. Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y (February 2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions". The Journal of Biological Chemistry. 278 (6): 4103–11. doi:10.1074/jbc.M209832200. PMID 12446711.

Further reading


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