SSX4 (gene)

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.[5]

SSX4
Identifiers
AliasesSSX4, CT5.4, synovial sarcoma, X breakpoint 4, SSX family member 4
External IDsOMIM: 300326 MGI: 2446771 HomoloGene: 133052 GeneCards: SSX4
Orthologs
SpeciesHumanMouse
Entrez

6759

387132

Ensembl

ENSG00000268009

ENSMUSG00000023165

UniProt

O60224

n/a

RefSeq (mRNA)

NM_175729
NM_005636

NM_001001450
NM_001134226

RefSeq (protein)

NP_005627
NP_783856

n/a

Location (UCSC)Chr X: 48.38 – 48.39 MbChr X: 8.32 – 8.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000268009 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023165 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SSX4 synovial sarcoma, X breakpoint 4".

Further reading


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