STAP1

Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.[5][6][7]

STAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAP1, BRDG1, STAP-1, signal transducing adaptor family member 1
External IDsOMIM: 604298 MGI: 1926193 HomoloGene: 8103 GeneCards: STAP1
Orthologs
SpeciesHumanMouse
Entrez

26228

56792

Ensembl

ENSG00000035720

ENSMUSG00000029254

UniProt

Q9ULZ2

Q9JM90

RefSeq (mRNA)

NM_012108
NM_001317769

NM_019992
NM_001310639

RefSeq (protein)

NP_001304698
NP_036240

NP_001297568
NP_064376

Location (UCSC)Chr 4: 67.56 – 67.61 MbChr 5: 86.22 – 86.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.[7]

Interactions

STAP1 has been shown to interact with C19orf2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000035720 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029254 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Nov 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc Natl Acad Sci U S A. 96 (21): 11976–81. Bibcode:1999PNAS...9611976O. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.
  6. Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M (Mar 2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.
  7. "Entrez Gene: BRDG1 BCR downstream signaling 1".
  8. Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.

Further reading


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