STAU2
Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.[5][6]
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| Aliases | STAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605920 MGI: 1352508 HomoloGene: 8666 GeneCards: STAU2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.[6] Expression of Stau2 was sufficient to increase eye size, suggesting a novel biological role of Stau2 in eye morphogenesis.[7] Acting as a HIV-1 dependency factor, Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev [8] and recently it was reported that Staufen-2 is incorporated into HIV-1 particles and boost viral infectivity[9]
References
- GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
- "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".
- Cockburn, Diane M.; Charish, Jason; Tassew, Nardos G.; Eubanks, James; Bremner, Rod; Macchi, Paolo; Monnier, Philippe P. (November 2012). "The double-stranded RNA-binding protein Staufen 2 regulates eye size". Molecular and Cellular Neuroscience. 51 (3–4): 101–111. doi:10.1016/j.mcn.2012.08.008. PMID 22940085. S2CID 5193038.
- Banerjee, Atoshi; Benjamin, Ronald; Balakrishnan, Kannan; Ghosh, Payel; Banerjee, Sharmistha (2014-02-13). "Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev". Retrovirology. 11: 18. doi:10.1186/1742-4690-11-18. ISSN 1742-4690. PMC 4016256. PMID 24520823.
- Balakrishnan, Kannan; Jaguva Vasudevan, Ananda; Mohareer, Krishnaveni; Luedde, Tom; Münk, Carsten; Banerjee, Sharmistha (2021-12-08). "Encapsidation of Staufen-2 Enhances Infectivity of HIV-1". Viruses. 13 (12): 2459. doi:10.3390/v13122459. ISSN 1999-4915. PMC 8703407. PMID 34960728.
Further reading
- Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
- Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
- Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. doi:10.1242/jcs.115.16.3285. PMID 12140260.
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