STX10

Syntaxin-10 (STX10) is a SNARE protein that is encoded by the STX10 gene.[3] This protein is found in most vertebrates (including humans) but is noticeably absent from mice.[4][5] As with other SNARE proteins, STX10 facilitates vesicle fusion and thus is important for intracellular trafficking of proteins and other cellular components. More specifically, STX10 has been implicated in endosome to Golgi trafficking of the mannose 6-phosphate receptor[4] and glucose transporter type 4.[5]

STX10
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSTX10, SYN10, hsyn10, syntaxin 10
External IDsOMIM: 603765 HomoloGene: 84379 GeneCards: STX10
Orthologs
SpeciesHumanMouse
Entrez

8677

n/a

Ensembl

ENSG00000104915

n/a

UniProt

O60499

n/a

RefSeq (mRNA)

NM_001271609
NM_001271610
NM_001271611
NM_003765

n/a

RefSeq (protein)

NP_001258538
NP_001258539
NP_001258540
NP_003756

n/a

Location (UCSC)Chr 19: 13.14 – 13.15 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

STX10 has been detected in the trans-Golgi network (TGN) by immunofluorescence.[3]

Structure and function

Human STX10 is a 249 amino acid protein that has three N-terminal α-helices and a single SNARE domain followed by a single-pass transmembrane domain. Human STX10 is 60% identical to human STX6.[3]

STX10 is structurally classified as a Qc-SNARE (contributes a glutamine (Q) residue in the formation of the assembled core SNARE complex) and is functionally classified as a t-SNARE (or target-SNARE which is often located in the membranes of target compartments).[6]

Interactions

STX10 is known to interact with the t-SNAREs VTI1A and STX16[7] and with the v-SNAREs VAMP3[4] and VAMP4.[7] The SNARE complex of STX10, STX16, VTI1A, and VAMP3 are required for late endosome to Golgi trafficking of the mannose 6-phosphate receptor.[4] Early endosome to Golgi trafficking of Shiga toxin requires the SNARE complex of STX6, STX16, VTI1A, and VAMP3 or VAMP4.[8]

Thus, STX10 distinguishes early endosome to Golgi trafficking from late endosome to Golgi trafficking.[4]

References
  1. GRCh38: Ensembl release 89: ENSG00000104915 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Tang BL, Low DY, Tan AE, Hong W (January 1998). "Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network". Biochemical and Biophysical Research Communications. 242 (2): 345–50. doi:10.1006/bbrc.1997.7966. PMID 9446797.
  4. Ganley IG, Espinosa E, Pfeffer SR (January 2008). "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells" (PDF). The Journal of Cell Biology. 180 (1): 159–72. doi:10.1083/jcb.200707136. PMC 2213607. PMID 18195106.
  5. Esk C, Chen CY, Johannes L, Brodsky FM (January 2010). "The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step". The Journal of Cell Biology. 188 (1): 131–44. doi:10.1083/jcb.200908057. PMC 2812854. PMID 20065094.
  6. Hong W (July 2005). "SNAREs and traffic". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1744 (3): 493–517. doi:10.1016/j.bbamcr.2005.03.014. PMID 16038056.
  7. Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang BL (Jul–Aug 2005). "Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16". Molecular Membrane Biology. 22 (4): 313–25. doi:10.1080/09687860500143829. PMID 16154903. S2CID 25014829.
  8. Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (February 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-10 (STX10)
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