SUGT1

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.[5][6]

SUGT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUGT1, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
External IDsOMIM: 604098 MGI: 1915205 HomoloGene: 4877 GeneCards: SUGT1
Orthologs
SpeciesHumanMouse
Entrez

10910

67955

Ensembl

ENSG00000165416

ENSMUSG00000022024

UniProt

Q9Y2Z0

Q9CX34

RefSeq (mRNA)

NM_001130912
NM_006704
NM_001320831

NM_026474

RefSeq (protein)

NP_001124384
NP_001307760
NP_006695

NP_080750

Location (UCSC)Chr 13: 52.65 – 52.7 MbChr 14: 79.83 – 79.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.[6]

Interactions

SUGT1 has been shown to interact with S100A6.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000165416 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022024 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
  6. "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
  7. Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.

Further reading


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