SURF4

SURF4
Identifiers
Aliases	SURF4, ERV29, surfeit 4
External IDs	OMIM: 185660 MGI: 98445 HomoloGene: 6052 GeneCards: SURF4
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	133,376,166 bp[1]
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; stromal cell of endometrium; ; duodenum; ; body of pancreas; ; placenta; ; right lobe of liver; ; gallbladder; ; smooth muscle tissue; ; left adrenal gland; ; left uterine tube;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum; membrane; endoplasmic reticulum-Golgi intermediate compartment; transport vesicle; endoplasmic reticulum membrane; Golgi membrane; plasma membrane; azurophil granule membrane; cytosol;
Biological process	early endosome to Golgi transport; positive regulation of organelle organization; protein exit from endoplasmic reticulum; Golgi organization; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	6836
	20932
	ENSG00000148248; ENSG00000280951
	n/a
	O15260
	Q64310
NM_001280788; NM_001280789; NM_001280790; NM_001280791; NM_001280792;
	NM_001280793; NM_033161
	NM_011512
NP_001267717; NP_001267718; NP_001267719; NP_001267720; NP_001267721;
	NP_001267722; NP_149351
	NP_035642
	Wikidata
View/Edit Human	View/Edit Mouse

Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies.[4][5] Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9.[4] It recognizes cargo proteins via a three-amino-acid sequence near the N-termini.[4] The related protein in yeast is called Erv29p.[5]

This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.[6]

Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.[4]

References

ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.
"SURF4 Gene - Surfeit 4". Retrieved 8 June 2022.
"Entrez Gene: SURF4 surfeit 4".

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[refGRCh38Ensembl-1] ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Sun2021-4] Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.

[GeneCards-5] "SURF4 Gene - Surfeit 4". Retrieved 8 June 2022.

[entrez-6] "Entrez Gene: SURF4 surfeit 4".