SYTL2

Synaptotagmin-like 2, also known as SYTL2, is a human gene.[5]

SYTL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYTL2, CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A, synaptotagmin like 2
External IDsOMIM: 612880 MGI: 1933366 HomoloGene: 131343 GeneCards: SYTL2
Orthologs
SpeciesHumanMouse
Entrez

54843

83671

Ensembl

ENSG00000137501

ENSMUSG00000030616

UniProt

Q9HCH5

Q99N50

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 11: 85.69 – 85.81 MbChr 7: 89.95 – 90.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.[5]

Interactions

SYTL2 has been shown to interact with RAB27A.[6][7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000137501 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030616 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SYTL2 synaptotagmin-like 2".
  6. Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
  7. Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". The Journal of Biological Chemistry. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
  8. Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.

Further reading


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