Sammy Lee (scientist)

Sammy Lee (born Samuel Lee, 1958 – 21 July 2012) was an expert on fertility[1] and in vitro fertilisation[2][3]

This article is about the British in vitro fertilisation research scientist. For other persons named Sammy Lee, see Sammy Lee.

He was a hospital scientific consultant and was the chief scientist at the Wellington IVF programme.[4] His book Counselling in Male Infertility was published in 1996; he contributed to major newspaper articles and appeared on several current affairs television programmes. He was the "inspiration" for Anthony Ling, the character in the novel One Life by Rebecca Frayn (Simon & Schuster 2006, ISBN 0-7432-6876-8), after the author herself sought Lee's help for IVF treatment.[5]

In 2010, Willing to Die for It, Lee's biography by Frances Lynn was published by Murray Print.[6]

Lee died suddenly on 21 July 2012.[3]

Current research

Lee's interests lay in the field of stem cell biology and regenerative medicine. He was a visiting professor at the University College London where he collaborated with various groups in the Anatomy Department examining the potential of bone marrow derived mesenchymal stem cells to give rise to neuronal/glial lineages in response to various growth factors and tissue culture manipulations. He also taught ethics of biomedicine at University College London.

In addition, he was interested in tissue engineering and teaching ethics in reproduction. He was attached to the Jessen-Mirsky laboratory and was studying remyelination. Lee had ethical committee approval in Brasil for creating artificial gametes from umbilical cord blood derived stem cells. It is hoped these will be used to overcome infertility.[7]

Biography

Lee originally researched his Ph.D. at UCL under the supervision of Professor Ricardo Miledi FRS in the school of Sir Bernard Katz.[8] Lee was also a signatory to a memento presented to Sir Bernard Katz on his 80th birthday from bona fide members of the school-occasion when the phrase "School of Katz" was coined.[9]

Lee first published research in Neuroscience during the 1980s (from the Biophysics department at UCL), having worked on nerve muscle interaction ranging from examining TTX-resistant action potentials in denervated muscle [10] to studying cholinesterase activity in dissociated adult muscle fibres [11] following up on the work first done in the same department by Bill Betz and Bert Sakmann.[12][13] Lee changed his focus to embryos, when he realised that many of the questions framed by his Neuroscience research were rooted in the matter of differentiation. The ultimate undifferentiated cell is the fertilised egg. This led Lee to work on gap junctions in early mammalian embryos (in the Anatomy & Embryology department at UCL), where work with Anne Warner FRS and Anne McLaren DBE FRS produced new information on factors affecting communication between cells and their developmental potential.[14][15]

Lee became a clinical embryologist in 1985, when working with the gynaecologist Ian Craft[16] he directed the IVF laboratory at the Wellington Hospital in London, then one of the largest units in the world. Consultancy work with the UK division of Ares Serono (1986–1994) also involved work with the Bourn Hallam Group, which Patrick Steptoe and Bob Edwards had set up after Louise Brown's birth. From 1995 to 2002 he was based at the Portland Hospital for Women & Children.[17][18]

Lee latterly became based again at UCL. He was interested in tissue engineering and teaching ethics in reproduction.[19] He was working on tissue engineering and stem cells mainly concerned with background research on Stem cells and Progenitor cells. Dr. Lee also had a keen interest in ethics and expressed this at UCL by running a course titled "Ethics of Fertility and Embryo Research". His students remarked him to be knowledgeable in the field of ethics and enthusiastic; they had particularly noted that he is clearly a fan of Kant.

He had previously served as an international editor of the Brazilian Journal of Assisted Reproduction. He served as a Trustee and director of several charities. His curriculum vitae lists numerous scientific publications. He was elected as a fellow of the Royal Society of Health (now Royal Society for Public Health) and the Royal Society of Medicine, both in 1987.[20]

Lee's team at the Wellington pioneered the first UK practise of gamete Intra-fallopian Transfer (GIFT), The GIFT of Life (a technique invented by Ricardo Asch in the USA). The team was the second to carry out GIFT and then proceeded to post the largest series in the world in 1986.[21][22]

Lee also helped perform some of the first egg donations in the UK, when directing the Wellington Hospital IVF Laboratory.[23]

Lee pioneered a simple inexpensive efficient form of Mechanical Assisted Hatching in the UK. He produced the world's first intra-cytoplasmic sperm injection (ICSI with NASBA virus assay) virus free baby to an HIV discordant couple.[24]

Lee had many media appearances having been on many TV shows as well as writing a number of newspapers articles . He wrote several books of his own: such as Counselling in Male Infertility, and was also a contributor/consultant in such books: The Miraculous World of The Unborn Baby (Quadrillion, Godalming, Surrey 1998) ISBN 1-85833-966-9, Natural Fertility (Hamlyn 2002) ISBN 0-600-60396-2 and Inconceivable Conceptions.

Lee was no stranger to controversy. In addition to his work in IVF, he had differences of opinion with the HFEA, most notably over the issue of human cloning.[25] He states that if it may be done safely and effectively, and be morally justifiable.

Lee also wrote an article in the Sunday Times (10 November 2002) in the aftermath of a number of high-profile embryo transfer mixups in several human IVF clinics.

Professor Sammy Lee arranged a conference co-sponsored by the Progress Educational Trust entitled '21st Century Motherhood' at the University College London (UCL) (18 September 2009). Speakers included Peter Brinsden, Consultant Medical Director at Bourn Hall Clinic, Professor Lord Robert Winston and Professor Shere Hite[26][27] .[28]

Education and experience

Lee was educated at Mill Hill School and received a B.Sc. in Physiology in 1979 from Chelsea College, (later merged into King's College London). He received a Ph.D. in Biophysics from University College London under the supervision of Prof. Ricardo Miledi, in a group associated with Sir Bernard Katz. He later received a Diploma in Counselling from London Hospital Medical College in 1991, and in 2004 a PGCE at the University of Greenwich.

Lee held the following appointments:

  • Research Associate in Biophysics (1982–1984), and Anatomy & Embryology (1984–1985) University College London
  • Laboratory Director, IVF unit at the Humana Hospital Wellington in London (1985–1986)[21][22]
  • Consultant Clinical Embryologist, UK division of Ares Serono (human recombinant pharmaceutical company) [22]
  • Scientific Director of the Colchester Fertility Service (1992 to 2001)
  • Consultant Scientist and Director of intracytoplasmic sperm injection (ICSI) at the Portland Hospital for Women & Children (1995–2003)
  • Acting Scientific Director for the Chelsea & Westminster Hospital (1999–2000).
  • Honorary Senior Research Fellow in Reproductive Medicine at the Homerton Hospital (2000–2005)
  • Honorary Lecturer in the Anatomy & Developmental Biology Dept., University College London (2003–present).[19]
  • Visiting Professor in Biomedical Science at the ABC Medical School in São Paulo, Brasil (2006–present).[29]

References
  1. Hill, Amelia (13 September 2009). "Women are risking their lives to have IVF babies". The Guardian.
  2. "Paying poor women for eggs is 'a Kind of Prostitution' says expert". The Times. 19 September 2009. Archived from the original on 12 September 2012.
  3. "Obituary: Professor Samuel Lee". BioNews. 28 August 2012.
  4. Parry, Vivienne (22 September 2009). "Why are older mothers still taboo?". The Times. Archived from the original on 8 October 2009.
  5. Frayn, Rebecca (30 August 2009). "Rebecca Frayn: I just wanted a baby. I didn't even care if it put my life in danger". The Independent.
  6. Lynn, Frances (2010). Willing To Die For It. Murray Print. ISBN 978-0-9539089-1-2.
  7. "Dr Samuel Lee: Honorary Teaching Fellow". UCL Research Department of Cell and Developmental Biology. Archived from the original on 26 April 2010. Retrieved 23 September 2009. Official UCL page
  8. The School of Sir Bernard Katz
  9. Lee provided an anecdote about Sir Bernard Katz and Ricardo Miledi. ISBN 88-86062-55-9 Published by CESI
  10. Lee S, Miledi R, Ruzzier F (1987). "Rat diaphragm muscle fibre action potentials and the development of tetrodotoxin resistance in long-term organ culture". Quarterly Journal of Experimental Physiology. 72 (4): 601–608. doi:10.1113/expphysiol.1987.sp003100. PMID 2827223.
  11. Glavinovic MI, Lee S, Miledi R (1987). "Effect of collagenase treatment on rat muscle fibre acetylcholinesterase activity". J. Neurosci. Res. 18 (4): 519–524. doi:10.1002/jnr.490180403. PMID 2830412. S2CID 19904911. Archived from the original on 5 January 2013.
  12. Betz W.J.; Sakmann B. (1971). "Disjunction" of frog neuromuscular synapses by treatment with proteolytic enzymes". Nature New Biology. 232 (29): 94–95. doi:10.1038/newbio232094a0. hdl:21.11116/0000-0001-3090-5. PMID 4328253.
  13. Betz W.J.; Sakmann B. (1973). "Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions". J. Physiol. 230 (3): 673–688. doi:10.1113/jphysiol.1973.sp010211. PMC 1350622. PMID 4352108.
  14. Buehr M, Lee S, McLaren A, Warner A (1987). "Reduced gap junctional communication is associated with the lethal condition characteristic of DDK mouse eggs fertilized by foreign sperm". Development. 101 (3): 449–459. doi:10.1242/dev.101.3.449. PMID 3502992.
  15. Lee S, Gilula NB, Warner A (1987). "Gap junctional communication and compaction during preimplantation stages of mouse development". Cell. 51 (5): 851–860. doi:10.1016/0092-8674(87)90108-5. PMID 3677175. S2CID 42791291.
  16. The Daily Telegraph Letter from Ian Craft when he and Sammy Lee worked at the Wellington
  17. Official UCL page Archived 3 February 2009 at archive.today
  18. Dr Sammy Lee, Scientific Director of the Portland Hospital, David McConnell, Professor of Genetics at TCD, and David Quinn, Editor of the Irish Catholic, discuss the issue
  19. S. Lee (2007). "UCL staff webpage". UCL. Archived from the original on 4 May 2007.
  20. UCL Staff Page (1987) Lee was FRSM and FRSH. He was inducted to Fellowship of RSH (now RSPH) and RSM. "UCL Research Dept. Cell & Developmental Biology". Archived from the original on 26 April 2010. Retrieved 23 September 2009.
  21. J Laurance (30 October 1987). "The test tube dilemma". New Society.
  22. C Harrison (January 1991). "Failing to deliver". Public Eye. BBC.
  23. "Society announcement". 1 (6). 1 September 1986. Archived from the original on 13 July 2012. {{cite journal}}: Cite journal requires |journal= (help)
  24. Lee S.; Rivas-Toro H (2001). "Treatment with IUI and ICSI for HIV men whose partners remain HIV- free: a risk reduction method". J. Bras. Reprod. Ass. 5: 64–65.
  25. BBC News Dr Sammy Lee and Ruth Deech head of the UK human fertilisation authority
  26. Times On Line 'Cultural historian Shere Hite says it’s just sexism '
  27. UCL '21st Century Motherhood' Conference at the University College London (UCL) (18 September 2009)
  28. In this podcast Professor Sammy Lee (chair of the conference, Visiting Professor in Biomedical Science ABC Medical School São Paulo, and Honorary Teaching Fellow at UCL), Lord Robert Winston (Imperial College) and Professor Naomi Pfeffer (Historian and Sociologist, London Metropolitan University) debate the issue and talk about the implications, both from a socio/historical and biological perspective. They cover topics such as IVF tourism, egg freezing and the money to be made from making babies
  29. Faculdade De Medicina Do ABC Information about the faculty

Further reading

Bibliography

Selected journal articles

Newspaper articles

Books & book chapters/contributions
  • S Lee (1996). Counselling in male infertility. Oxford: Blackwell Scientific Press. ISBN 0-632-03906-X.
  • S. Lee (2003). "Myths and reality in male infertility". In J. Haynes; amp; J. Miller (eds.). Inconceivable conceptions. Routledge. ISBN 1-58391-168-5.
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