Saturation (genetic)

Genetic saturation is the result of multiple substitutions at the same site in a sequence, or identical substitutions in a different sequence, such that the apparent sequence divergence rate is lower than the actual divergence that has occurred.[1] In phylogenetics, saturation effects result in long branch attraction, where the most distant lineages have misleadingly short branch lengths. It also decreases phylogenetic information contained in the sequences.[2]

Genetic saturation occurs most rapidly on fast-evolving sequences, such as the hypervariable region of mitochondrial DNA, or in Short tandem repeats such as on the Y-chromosome.[3][4]

See also

References
  1. Philippe H, Brinkmann H, Lavrov DV, Littlewood DT, Manuel M, Wörheide G, Baurain D (March 2011). "Resolving difficult phylogenetic questions: why more sequences are not enough". PLOS Biology. 9 (3): e1000602. doi:10.1371/journal.pbio.1000602. PMC 3057953. PMID 21423652.
  2. Abylgazieva NA (2003-01-01). "[Case of "renal diabetes"]". Zdravookhranenie Kirgizii. 26 (3): 49–51. doi:10.1016/S1055-7903(02)00326-3. PMID 7903.
  3. Henn BM, Gignoux CR, Feldman MW, Mountain JL (January 2009). "Characterizing the time dependency of human mitochondrial DNA mutation rate estimates". Molecular Biology and Evolution. 26 (1): 217–30. doi:10.1093/molbev/msn244. PMID 18984905.
  4. Ho SY, Phillips MJ, Cooper A, Drummond AJ (July 2005). "Time dependency of molecular rate estimates and systematic overestimation of recent divergence times". Molecular Biology and Evolution. 22 (7): 1561–8. doi:10.1093/molbev/msi145. PMID 15814826.
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