Scytalone dehydratase

The enzyme scytalone dehydratase (EC 4.2.1.94) catalyzes the chemical reaction

scytalone 1,3,8-trihydroxynaphthalene + H2O
scytalone dehydratase
Identifiers
EC no.4.2.1.94
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming). This enzyme is also called scytalone 7,8-hydro-lyase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1IDP, 1STD, 2STD, 3STD, 4STD, 5STD, 6STD, and 7STD.

References

    • Butler MJ, Lazarovits G, Higgins VJ, Lachance MA (1988). "Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi". Exp. Mycol. 12 (4): 367–376. doi:10.1016/0147-5975(88)90028-X.
    • Tajima S, Kubo Y, Furusawa I, Shishiyama J (1989). "Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus". Exp. Mycol. 13: 69–76. doi:10.1016/0147-5975(89)90009-1.
    • Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)90004-7.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.