Serine hydroxymethyltransferase 2

SHMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OU5, 4PVF
Identifiers
Aliases	SHMT2, GLYA, HEL-S-51e, SHMT, serine hydroxymethyltransferase 2, NEDCASB
External IDs	OMIM: 138450 MGI: 1277989 HomoloGene: 133984 GeneCards: SHMT2
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	57,234,935 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	127,358,313 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of liver; ; oocyte; ; stromal cell of endometrium; ; secondary oocyte; ; embryo; ; body of pancreas; ; tibia; ; ganglionic eminence; ; parotid gland; ; lymph node;
	Top expressed in
	left lobe of liver; ; condyle; ; kidney; ; yolk sac; ; proximal tubule; ; internal carotid artery; ; somite; ; calvaria; ; fossa; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; amino acid binding; chromatin binding; L-allo-threonine aldolase activity; protein binding; catalytic activity; identical protein binding; glycine hydroxymethyltransferase activity; pyridoxal phosphate binding; zinc ion binding; cobalt ion binding; serine binding;
Cellular component	membrane; BRISC complex; microtubule cytoskeleton; mitochondrial intermembrane space; extracellular exosome; mitochondrial inner membrane; cytoplasm; mitochondrion; mitochondrial matrix; mitochondrial nucleoid; nucleus;
Biological process	L-serine biosynthetic process; tetrahydrofolate interconversion; protein tetramerization; tetrahydrofolate metabolic process; protein K63-linked deubiquitination; folic acid metabolic process; glycine biosynthetic process from serine; response to type I interferon; positive regulation of cell population proliferation; glycine biosynthetic process; protein homotetramerization; one-carbon metabolic process; glycine metabolic process; L-serine metabolic process; regulation of oxidative phosphorylation; L-serine catabolic process; regulation of mitochondrial translation; regulation of aerobic respiration; cellular response to tetrahydrofolate;
	Sources:Amigo / QuickGO
Orthologs
	6472
	108037
	ENSG00000182199
	ENSMUSG00000025403
	P34897
	Q9CZN7
	NM_001166356; NM_001166357; NM_001166358; NM_001166359; NM_005412
	NM_001252316; NM_028230
	NP_001159828; NP_001159829; NP_001159830; NP_001159831; NP_005403
	NP_001239245; NP_082506
	Wikidata
View/Edit Human	View/Edit Mouse

Serine hydroxymethyltransferase 2 is an enzyme that in humans is encoded by the SHMT2 gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000182199 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025403 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Anderson DD, Stover PJ (June 2009). "SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis". PLOS ONE. 4 (6): e5839. Bibcode:2009PLoSO...4.5839A. doi:10.1371/journal.pone.0005839. PMC 2688753. PMID 19513116.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182199 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025403 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19513116-5] Anderson DD, Stover PJ (June 2009). "SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis". PLOS ONE. 4 (6): e5839. Bibcode:2009PLoSO...4.5839A. doi:10.1371/journal.pone.0005839. PMC 2688753. PMID 19513116.