Serralysin
Serralysin (EC 3.4.24.40, Pseudomonas aeruginosa alkaline proteinase, Escherichia freundii proteinase, Serratia marcescens extracellular proteinase, Serratia marcescens metalloproteinase, Pseudomonas aeruginosa alk. protease, Serratia marcescens metalloprotease) is an enzyme.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction
- Preferential cleavage of bonds with hydrophobic residues in P1'
| Serralysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.40 | ||||||||
| CAS no. | 70851-98-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This extracellular endopeptidase is present in Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi.
References
- Morihara K, Tsuzuki H, Oka T (March 1968). "Comparison of the specificities of various neutral proteinases from microorganisms". Archives of Biochemistry and Biophysics. 123 (3): 572–88. doi:10.1016/0003-9861(68)90179-3. PMID 4967801.
- Morihara K, Tsuzuki H, Oka T (June 1973). "On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides". Biochimica et Biophysica Acta (BBA) - Enzymology. 309 (2): 414–29. doi:10.1016/0005-2744(73)90040-5. PMID 4199986.
- Nakajima M, Mizusawa K, Yoshida F (May 1974). "Purification and properties of an extracellular proteinase of psychrophilic Escherichia freundii". European Journal of Biochemistry. 44 (1): 87–96. doi:10.1111/j.1432-1033.1974.tb03460.x. PMID 4212288.
- Decedue CJ, Broussard EA, Larson AD, Braymer HD (August 1979). "Purification and characterization of the extracellular proteinase of Serratia marcescens". Biochimica et Biophysica Acta (BBA) - Enzymology. 569 (2): 293–301. doi:10.1016/0005-2744(79)90065-2. PMID 383155.
- Doerr M, Traub WH (May 1984). "Purification and characterization of two Serratia marcescens proteases". Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology. 257 (1): 6–19. PMID 6380155.
- Nakahama K, Yoshimura K, Marumoto R, Kikuchi M, Lee IS, Hase T, Matsubara H (July 1986). "Cloning and sequencing of Serratia protease gene". Nucleic Acids Research. 14 (14): 5843–55. doi:10.1093/nar/14.14.5843. PMC 311595. PMID 3016665.
- Dahler GS, Barras F, Keen NT (October 1990). "Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16". Journal of Bacteriology. 172 (10): 5803–15. doi:10.1128/jb.172.10.5803-5815.1990. PMC 526898. PMID 2211513.
- Okuda K, Morihara K, Atsumi Y, Takeuchi H, Kawamoto S, Kawasaki H, Suzuki K, Fukushima J (December 1990). "Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455". Infection and Immunity. 58 (12): 4083–8. doi:10.1128/IAI.58.12.4083-4088.1990. PMC 313780. PMID 2123832.
External links
- Serralysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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