Sibiromycin

Sibiromycin is an antitumor antibiotic with the molecular formula C24H33N3O7 which is produced by the bacterium Streptosporangium sibiricum.[1][2][3][4] Sibiromycin is a pyrrolobenzodiazepine.[5][6]

Sibiromycin
Names
IUPAC name
(6R,6aS)-2-[(2S,3R,4R,5S,6S)-3,4-dihydroxy-4,6-dimethyl-5-(methylamino)oxan-2-yl]oxy-4,6-dihydroxy-3-methyl-8-[(E)-prop-1-enyl]-5,6,6a,7-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one[1]
Other names
Sybiromycin[1]
Identifiers
Properties
C24H33N3O7
Molar mass 475.542 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. "Sibiromycin". Pubchem.ncbi.NLM.nih.gov.
  2. Gause, G. F. (1975). "Sibiromycin". Mechanism of Action of Antimicrobial and Antitumor Agents. pp. 269–273. doi:10.1007/978-3-642-46304-4_17. ISBN 978-3-642-46306-8.
  3. Li, Wei; Khullar, Ankush; Chou, ShenChieh; Sacramo, Ashley; Gerratana, Barbara (May 2009). "Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic". Applied and Environmental Microbiology. 75 (9): 2869–2878. Bibcode:2009ApEnM..75.2869L. doi:10.1128/AEM.02326-08. PMC 2681668. PMID 19270142.
  4. Rhoads, Robert E. (6 December 2012). Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970. Springer Science & Business Media. p. 33. ISBN 978-3-642-65141-0.
  5. Antibiotics and Chemotherapy. S. Karger. 1980. p. 105. ISBN 978-3-8055-2830-6.
  6. Rahman, Khondaker Miraz; Thurston, David E. (6 September 2018). Small-Molecule Transcription Factor Inhibitors in Oncology. Royal Society of Chemistry. p. 87. ISBN 978-1-78262-145-4.

Further reading
  • Kersten, H.; Kersten, W. (11 November 2013). Inhibitors of Nucleic Acid Synthesis: Biophysical and Biochemical Aspects. Springer Science & Business Media. p. 19. ISBN 978-3-642-80855-5.
  • Corcoran, John W. (6 December 2012). Biosynthesis. Springer Science & Business Media. p. 277. ISBN 978-3-642-67724-3.
  • Comprehensive Natural Products III. Elsevier. 22 July 2020. p. 412. ISBN 978-0-08-102691-5.
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