Sjögren syndrome antigen B

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.[5]

SSB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSSB, LARP3, La, La/Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La
External IDsOMIM: 109090 MGI: 98423 HomoloGene: 2366 GeneCards: SSB
Orthologs
SpeciesHumanMouse
Entrez

6741

20823

Ensembl

ENSG00000138385

ENSMUSG00000068882

UniProt

P05455

P32067

RefSeq (mRNA)

NM_003142
NM_001294145

NM_001110145
NM_009278
NM_001355265

RefSeq (protein)

NP_001281074
NP_003133

NP_001103615
NP_033304
NP_001342194

Location (UCSC)Chr 2: 169.79 – 169.81 MbChr 2: 69.69 – 69.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.[5][6]

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.[7]

See also


References

  1. GRCh38: Ensembl release 89: ENSG00000138385 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000068882 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)".
  6. Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (January 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Molecular Cell. 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMC 4689297. PMID 16387655.
  7. Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904.

Further reading

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