Slc22a21
Solute carrier family 22 (organic cation transporter), member 21 is a protein that in the house mouse is encoded by the Slc22a21 gene.[1] The gene is also known as Octn3 and Slc22a9.[1] Slc22a21 belongs to a protein family of solute carriers.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal[2] |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Plasma immunoglobulins | Normal |
| Haematology | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Tail epidermis wholemount | Normal |
| Skin Histopathology | Normal |
| Brain histopathology | Normal |
| Salmonella infection | Normal[3] |
| Citrobacter infection | Normal[4] |
| All tests and analysis from[5][6] |
Model organisms have been used in the study of Slc22a21 function. A conditional knockout mouse line, called Slc22a21tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[5]
References
- "Solute carrier family 22 (organic cation transporter), member 21". Retrieved 2011-12-11.
- "Indirect calorimetry data for Slc22a21". Wellcome Trust Sanger Institute.
- "Salmonella infection data for Slc22a21". Wellcome Trust Sanger Institute.
- "Citrobacter infection data for Slc22a21". Wellcome Trust Sanger Institute.
- Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
- Mouse Resources Portal, Wellcome Trust Sanger Institute.
- "International Knockout Mouse Consortium".
- "Mouse Genome Informatics".
- Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
- van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
Further reading
- Tamai, I.; Ohashi, R.; Nezu, J. I.; Sai, Y.; Kobayashi, D.; Oku, A.; Shimane, M.; Tsuji, A. (2000). "Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice". Journal of Biological Chemistry. 275 (51): 40064–40072. doi:10.1074/jbc.M005340200. PMID 11010964.
- Monte, J. C.; Nagle, M. A.; Eraly, S. A.; Nigam, S. K. (2004). "Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa". Biochemical and Biophysical Research Communications. 323 (2): 429–436. doi:10.1016/j.bbrc.2004.08.112. PMID 15369770.
- Lamhonwah, A. M.; Ackerley, C. A.; Tilups, A.; Edwards, V. D.; Wanders, R. J.; Tein, I. (2005). "OCTN3 is a mammalian peroxisomal membrane carnitine transporter". Biochemical and Biophysical Research Communications. 338 (4): 1966–1972. doi:10.1016/j.bbrc.2005.10.170. PMID 16288981.
- Lamhonwah, A. M.; Skaug, J.; Scherer, S. W.; Tein, I. (2003). "A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)". Biochemical and Biophysical Research Communications. 301 (1): 98–101. doi:10.1016/S0006-291X(02)02946-7. PMID 12535646.
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