Sodium glycerophosphate

Sodium glycerophosphate, sold under the brand name Glycophos, is a medication used to supplement phosphate.[1][2] It is administered via intravenous infusion.[1][2]

Sodium glycerophosphate
Clinical data
Trade namesGlycophos
AHFS/Drugs.comProfessional Drug Facts
Pregnancy
category
  • AU: Exempt
Routes of
administration		Intravenous infusion
ATC code
Legal status
Legal status
  • AU: Unscheduled
Identifiers
  • disodium 3-(phosphonooxy)propane-1,2-diol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC3H7Na2O6P
Molar mass216.036 g·mol−1
3D model (JSmol)
Melting point98 to 100 °C (208 to 212 °F)
Solubility in watervery soluble
  • [Na+].[Na+].OCC(O)COP([O-])([O-])=O
  • InChI=1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2
  • Key:GEKBIENFFVFKRG-UHFFFAOYSA-L
  • Key:OFNNKPAERNWEDD-UHFFFAOYSA-L

Sodium glycerophosphate is an organic phosphate salt.[1][2]

It was approved for medical use in Australia in November 2019.[3][1][4]

It is an unapproved medication in the United States that was used as a substitute for inorganic phosphate during a drug shortage.[2]

Chemistry

The substance is a mixture of disodium glycerol 1- and 2-phosphates, which have different amounts of water of crystallization; the total amount is 5+1⁄2 H2O per glycerol phosphate molecule. It is a white to off-white powder which may or may not be crystalline, has no discernible odor and tastes salty. It melts at 98 to 100 °C (208 to 212 °F) and decomposes at 130 °C (266 °F). Aqueous solutions have a pH of about 9.5.[5]

References
  1. "ARTG Entry:312021 Glycophos Product Information" (PDF). Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
  2. "Glycophos- sodium glycolate injection, solution". DailyMed. 16 January 2019. Retrieved 23 August 2020.
  3. "Glycophos Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
  4. "Summary for ARTG Entry:312021 Glycophos sodium glycerophosphate (as hydrate) 4.32 g/20 mL concentrated solution for injection ampoule". Therapeutic Goods Administration (TGA). Archived from the original on 18 April 2021. Retrieved 23 August 2020.
  5. Hagers Handbuch der pharmazeutischen Praxis (in German). Vol. VI.A (4th ed.). Springer. 15 August 1977. pp. 91–92. ISBN 3-540-05123-6.

Further reading


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