Sperm-associated antigen 9

C-jun-amino-terminal kinase-interacting protein 4 is a scaffold protein that in humans is encoded by the SPAG9 gene.[5][6][7]

SPAG9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPAG9, CT89, HLC-6, HLC4, JIP-4, JIP4, JLP, PHET, PIG6, HLC6, sperm associated antigen 9
External IDsOMIM: 605430 MGI: 1918084 HomoloGene: 2954 GeneCards: SPAG9
Orthologs
SpeciesHumanMouse
Entrez

9043

70834

Ensembl

ENSG00000008294

ENSMUSG00000020859

UniProt

O60271

Q58A65

RefSeq (mRNA)

NM_001130527
NM_001130528
NM_001251971
NM_003971
NM_172345

RefSeq (protein)

NP_001123999
NP_001124000
NP_001238900
NP_003962

Location (UCSC)Chr 17: 50.96 – 51.12 MbChr 11: 93.89 – 94.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.[7]

Clinical significance

SPAG9 is a potential biomarker for early cervical carcinoma[8] bladder cancer,[9] and lung cancer.[10]

Interactions

SPAG9 has been shown to interact with MAX.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000008294 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020859 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shankar S, Mohapatra B, Suri A (Feb 1998). "Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif". Biochemical and Biophysical Research Communications. 243 (2): 561–5. doi:10.1006/bbrc.1997.7943. PMID 9480848.
  6. Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. S2CID 247102.
  7. "Entrez Gene: SPAG9 sperm associated antigen 9".
  8. Garg M, Kanojia D, Salhan S, Suri S, Gupta A, Lohiya NK, Suri A (2009). "Sperm-associated antigen 9 is a biomarker for early cervical carcinoma". Cancer. 115 (12): 2671–83. doi:10.1002/cncr.24293. PMID 19326449. S2CID 23461660.
  9. Kanojia D, Garg M, Saini S, Agarwal S, Parashar D, Jagadish N, Seth A, Bhatnagar A, Gupta A, Kumar R, Lohiya NK, Suri A (2013). "Sperm associated antigen 9 plays an important role in bladder transitional cell carcinoma". PLOS ONE. 8 (12): e81348. Bibcode:2013PLoSO...881348K. doi:10.1371/journal.pone.0081348. PMC 3857194. PMID 24349057.
  10. Ren B, Wei X, Zou G, He J, Xu G, Xu F, Huang Y, Zhu H, Li Y, Ma G, Yu P (2016). "Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer". Oncology Reports. 35 (5): 2599–605. doi:10.3892/or.2016.4645. PMC 4811394. PMID 26934841.
  11. Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP (Oct 2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14189–94. Bibcode:2002PNAS...9914189L. doi:10.1073/pnas.232310199. PMC 137859. PMID 12391307.

Further reading


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