Steven Rosenberg

Steven A. Rosenberg (born 2 August 1940[1]) is an American cancer researcher and surgeon, chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He pioneered the development of immunotherapy that has resulted in the first effective immunotherapies and the development of gene therapy. He is the first researcher to successfully insert foreign genes into humans.

For the BBC Moscow foreign correspondent, see Steve Rosenberg. For the Major League Baseball pitcher, see Steve Rosenberg (baseball).
Steven Rosenberg
Born (1940-08-02) August 2, 1940
Alma materJohns Hopkins University
Harvard University
Scientific career
ThesisThe proteins of human erythrocyte membranes (1969)

Early life

Rosenberg was born in 1940, in the Bronx, the youngest of three children of Jewish immigrants from Poland,[2][1] who owned a luncheonette. He met his wife to be, Alice O’Connell during his residency at Boston’s Peter Bent Brigham Hospital, who was the chief nurse at the time. They got married in 1968 and have three daughters.[1]

Methodology

He is credited with developing the use of IL-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer.[3] He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of chemotherapy, immune cells and high doses of IL-2.[4] The second, in 2006, demonstrated that the receptor of T cells can be transferred to immune cells and in combination with chemotherapy and high doses of IL-2 can be used to treat patients with melanoma.[5] Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor cells modified with a gene for immune growth factors such as GM-CSF, had been used many years previously and continue to be used, although the efficacy of GM-CSF modified tumor lines as a cancer vaccine remain extremely modest, at best.[6] There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose IL-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose IL-2 was shown to be effective even in patients who had previously failed high-dose IL-2 treatment.

Rosenberg has pioneered the use of adoptive immunotherapy.

Education

Rosenberg graduated from the Bronx High School of Science. He received his B.A. (biology, 1961) and M.D. (1964) degrees from Johns Hopkins University.[1] He served a surgical internship and residency at the Peter Bent Brigham Hospital, completing it in 1974. During his residency he also earned a Ph.D. in biophysics from Harvard University with thesis titled The proteins of human erythrocyte membranes (in 1968/1969).[1] Following the completion of his surgical residency, he became the Chief of Surgery at the National Cancer Institute, a position he continues to hold.[1] His research has focused on the immunotherapy of cancer.

Awards and honors

See also

References
  1. "Steven A. Rosenberg Works to Unmask Cancer's Achilles Heel - the ASCO Post".
  2. Pollack, Andrew (August 1, 2016). "Setting the Body's 'Serial Killers' Loose on Cancer (Published 2016)". The New York Times.
  3. Wrangle, JM; Patterson, A; Johnson, CB; Neitzke, DJ; Mehrotra, S; Denlinger, CE; Paulos, CM; Li, Z; Cole, DJ; Rubinstein, MP (February 2018). "IL-2 and Beyond in Cancer Immunotherapy". Journal of Interferon & Cytokine Research. 38 (2): 45–68. doi:10.1089/jir.2017.0101. PMC 5815463. PMID 29443657.
  4. Dudley ME, Wunderlich JR, Robbins PF, et al. (October 2002). "Cancer regression and autoimmunity in patients after clonal re-population with antitumor lymphocytes". Science. 298 (5594): 850–4. Bibcode:2002Sci...298..850D. doi:10.1126/science.1076514. PMC 1764179. PMID 12242449.
  5. Morgan RA, Dudley ME, Wunderlich JR, et al. (October 2006). "Cancer regression in patients after transfer of genetically engineered lymphocytes". Science. 314 (5796): 126–9. Bibcode:2006Sci...314..126M. doi:10.1126/science.1129003. PMC 2267026. PMID 16946036.
  6. Jaffee EM, Hruban RH, Biedrzycki B, et al. (January 2001). "Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation". Journal of Clinical Oncology. 19 (1): 145–56. doi:10.1200/jco.2001.19.1.145. PMID 11134207.
  7. "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  8. "Trailblazing Researchers in Immunotherapy Selected to Receive Americas Most Distinguished Prize in Medicine". www.amc.edu.
  9. "2019 Edogawa NICHE Prize Awarded to Dr. Steven Rosenberg for His Pioneering Feat in Tackling Cancer with Immunotherapy". www.marketscreener.com.
  10. "Pioneering Physician-Scientist to Receive 2019 Szent-Györgyi Prize for Progress in Cancer Research". National Foundation for Cancer Research. 12 February 2019. Retrieved 24 February 2021.
  11. Dan David Prize 2021
  12. "Citation Laureates 2023_Physiology or Medicine". Citation Laureates. Clarivate. Archived from the original on September 19, 2023. Retrieved September 19, 2023.
  13. "NIH immunotherapy pioneer Steven Rosenberg awarded nation's highest honor for technology and innovation". National Institutes of Health (NIH). 2023-10-24. Retrieved 2023-10-24.
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