Stimulator of chondrogenesis 1
Stimulator of chondrogenesis 1 is a protein that in humans is encoded by the SCRG1 gene. [5]
| SCRG1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SCRG1, SCRG-1, stimulator of chondrogenesis 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603163 MGI: 1328308 HomoloGene: 5269 GeneCards: SCRG1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016].
References
- GRCh38: Ensembl release 89: ENSG00000164106 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000031610 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Stimulator of chondrogenesis 1". Retrieved 2018-10-01.
Further reading
- Aomatsu E, Takahashi N, Sawada S, Okubo N, Hasegawa T, Taira M, Miura H, Ishisaki A, Chosa N (January 2014). "Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells". Sci Rep. 4: 3652. Bibcode:2014NatSR...4E3652A. doi:10.1038/srep03652. PMC 3888969. PMID 24413464.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.