Streptomyces avermitilis

Streptomyces avermitilis is a species of bacteria in the genus Streptomyces. This bacterium was discovered by Satoshi Ōmura in Shizuoka Prefecture, Japan.

Streptomyces avermitilis
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Actinomycetota
Class: Actinomycetia
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species:
S. avermitilis
Binomial name
Streptomyces avermitilis
(ex Burg[1] et al. 1979) Kim and Goodfellow 2002[2]
Strains

Streptomyces avermitilis MA-4680

Synonyms

Streptomyces avermectinius Takahashi et al. 2002[3]

The first complete genome sequence of S. avermitilis was completed in 2003.[4] The genome consists of a single chromosome with a linear structure, unlike most bacterial genomes, which exist in the form of circular chromosomes.[5]

Avermectins are industrially derived from the fermentation products of S. avermitilis.[1][6] Avermectin itself was discovered by the Satoshi Ōmura group[6] and first disclosed in Burg et al. 1979.[1] One of the most widely employed drugs against nematode and arthropod infestations is the avermectin derivative ivermectin, as well as abamectin, a widely used insecticide and antihelmintic.

See also

References
  1. Burg, R. W.; Miller, B. M.; Baker, E. E.; Birnbaum, J.; Currie, S. A.; Hartman, R.; Kong, Y. L.; Monaghan, R. L.; Olson, G.; Putter, I.; Tunac, J. B.; Wallick, H.; Stapley, E. O.; Oiwa, R.; Omura, S. (1979). "Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation". Antimicrobial Agents and Chemotherapy. 15 (3): 361–367. doi:10.1128/AAC.15.3.361. PMC 352666. PMID 464561.
  2. Kim, S. B.; Goodfellow, M. (2002). "Streptomyces avermitilis sp. nov., nom. Rev., a taxonomic home for the avermectin-producing streptomycetes". International Journal of Systematic and Evolutionary Microbiology. 52 (Pt 6): 2011–2014. doi:10.1099/ijs.0.02265-0. PMID 12508861.
  3. Takahashi, Y.; Matsumoto, A.; Seino, A.; Ueno, J.; Iwai, Y.; Omura, S. (2002). "Streptomyces avermectinius sp. nov., an avermectin-producing strain". International Journal of Systematic and Evolutionary Microbiology. 52 (Pt 6): 2163–2168. doi:10.1099/ijs.0.02237-0. PMID 12508884.
  4. Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S (2003). "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis". Nat. Biotechnol. 21 (5): 526–531. doi:10.1038/nbt820. PMID 12692562.
  5. Paul Dyson (1 January 2011). Streptomyces: Molecular Biology and Biotechnology. Horizon Scientific Press. p. 5. ISBN 978-1-904455-77-6. Retrieved 16 January 2012.
  6. Martín, Juan F; Rodríguez-García, Antonio; Liras, Paloma (2017-03-15). "The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis". The Journal of Antibiotics. Japan Antibiotics Research Association (Nature Portfolio). 70 (5): 534–541. doi:10.1038/ja.2017.19. ISSN 0021-8820. PMID 28293039. S2CID 1881648.
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