Succinate-semialdehyde dehydrogenase (NADP+)
Succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79, succinic semialdehyde dehydrogenase (NADP+), succinyl semialdehyde dehydrogenase (NADP+), succinate semialdehyde:NADP+ oxidoreductase, NADP-dependent succinate-semialdehyde dehydrogenase, GabD) is an enzyme with systematic name succinate-semialdehyde:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- succinate semialdehyde + NADP+ + H2O succinate + NADPH + 2 H+
| Succinate-semialdehyde dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.79 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
References
- Bartsch K, von Johnn-Marteville A, Schulz A (December 1990). "Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD)". Journal of Bacteriology. 172 (12): 7035–42. doi:10.1128/jb.172.12.7035-7042.1990. PMC 210825. PMID 2254272.
- Jaeger M, Rothacker B, Ilg T (August 2008). "Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases". Biochemical and Biophysical Research Communications. 372 (3): 400–6. doi:10.1016/j.bbrc.2008.04.183. PMID 18474219.
External links
- Succinate-semialdehyde+dehydrogenase+(NADP+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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