Suliana Manley

Suliana Manley (born 1975) is an American biophysicist. Her research focuses on the development of high-resolution optical instruments, and their application in studying the organization and dynamics of proteins. She is a professor at École Polytechnique Fédérale de Lausanne and heads the Laboratory of Experimental Biophysics.[1][2][3]

Suliana Manley
Suliana Manley in her laboratory (2020)
Born1975 (age 47–48)
NationalityAmerican
Academic background
Alma materRice University
Academic work
InstitutionsÉcole Polytechnique Fédérale de Lausanne (EPFL)
Main interestsSuper-resolution fluorescence microscopy
Single molecule imaging in cells
Cellular biophysics
Bacterial cell cycle
Websitehttps://leb.epfl.ch

Career

Manley studied physics and mathematics at Rice University where she received a Bachelor’s degree (cum laude) in 1997.[2] She joined Harvard University and in 2004 graduated with a PhD in physics under the supervision of Dave A. Weitz.[4][5] She then went to work as a postdoctoral researcher on lipid bilayer and red blood cell membrane dynamics with Alice P. Gast at MIT.[6] In 2006, she joined the cell biology laboratory of Jennifer Lippincott-Schwartz at the National Institutes of Health as post-doctoral fellow. Here she developed an optical method (sptPALM) enabling the study of the dynamics of large ensembles of single proteins in membranes and inside cells.[7][8]

In 2009, she became an assistant professor of physics at the École Polytechnique Fédérale de Lausanne, and was promoted to associate professor in 2016 and to full professor in 2022.[3] She is the founding director of the Laboratory of Experimental Biophysics.[1][2]

Recognition

In 2019, Manley was awarded the Medal for Innovation in Light Microscopy by Royal Microscopical Society.[9] In 2020, she was elected as an APS (American Physical Society) fellow.[10]

Research

Manley's research group is invested in the field of high-resolution optical instruments and in the investigation of complex biological systems. They develop and deploy automated super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking. Their aim is to determine both the dynamics and the spatial distribution of protein assembly. They are also interested in the information transduction across cell membranes and therefore investigate the assembly dynamics of membrane-bound receptor.[11][12][13]

Their main research topics involve:

  • High-throughput and large field-of-view single molecule localization microscopies (SMLM) by application of microlens array (MLA)-based flat-field epi-illumination.[14][15][16]
  • Multicolor 3D single particle reconstruction from multicolor 2D SMLM images.[17][8]
  • Waveguide TIRF for high-throughput DNA-PAINT for better precision of target localization and continuous target sampling.[18]
  • Study of the physical and physiological signatures of mitochondria division and fusion.[19][20]

Publication

References
  1. "21 professors appointed at ETH Zurich and EPFL | ETH-Board". www.ethrat.ch. Retrieved 2020-09-17.
  2. "Prof. Suliana Manley". www.epfl.ch. Retrieved 2020-09-17.
  3. Testa, Andrea (2022-09-26). "Professor Suliana Manley promoted to Full Professor". {{cite journal}}: Cite journal requires |journal= (help)
  4. Cipelletti, Luca; Manley, S.; Ball, R. C.; Weitz, D. A. (2000-03-06). "Universal Aging Features in the Restructuring of Fractal Colloidal Gels". Physical Review Letters. 84 (10): 2275–2278. Bibcode:2000PhRvL..84.2275C. doi:10.1103/PhysRevLett.84.2275. PMID 11017262.
  5. Cipelletti, Luca; Ramos, Laurence; Manley, S.; Pitard, E.; Weitz, D. A.; Pashkovski, Eugene E.; Johansson, Marie (2003-01-13). "Universal non-diffusive slow dynamics in aging soft matter". Faraday Discussions. 123: 237–251. Bibcode:2003FaDi..123..237C. doi:10.1039/b204495a. PMID 12638864.
  6. "The Gast Group". web.mit.edu. Retrieved 2020-09-17.
  7. Patterson, George; Davidson, Michael; Manley, Suliana; Lippincott-Schwartz, Jennifer (2010-05-05). "Superresolution Imaging using Single-Molecule Localization". Annual Review of Physical Chemistry. 61 (1): 345–367. doi:10.1146/annurev.physchem.012809.103444. ISSN 0066-426X. PMC 3658623. PMID 20055680.
  8. Shtengel, G.; Galbraith, J. A.; Galbraith, C. G.; Lippincott-Schwartz, J.; Gillette, J. M.; Manley, S.; Sougrat, R.; Waterman, C. M.; Kanchanawong, P.; Davidson, M. W.; Fetter, R. D. (2009-03-03). "Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure". Proceedings of the National Academy of Sciences. 106 (9): 3125–3130. Bibcode:2009PNAS..106.3125S. doi:10.1073/pnas.0813131106. ISSN 0027-8424. PMC 2637278. PMID 19202073.
  9. Mel. "Medal Series". www.rms.org.uk. Retrieved 2020-09-17.
  10. "APS Fellow Archive". www.aps.org. Retrieved 2020-10-16.
  11. "Research". www.epfl.ch. Retrieved 2020-09-18.
  12. jake.saltzman@photonics.com, JAKE SALTZMAN, NEWS EDITOR. "Improved Illumination Design of Superresolution Microscope Technology". www.photonics.com. Retrieved 2020-09-18.{{cite web}}: CS1 maint: multiple names: authors list (link)
  13. "Getting a bigger picture with superresolution microscopy". Chemical & Engineering News. Retrieved 2020-09-18.
  14. Douglass, Kyle M.; Sieben, Christian; Archetti, Anna; Lambert, Ambroise; Manley, Suliana (2016-10-16). "Super-resolution imaging of multiple cells by optimized flat-field epi-illumination". Nature Photonics. 10 (11): 705–708. Bibcode:2016NaPho..10..705D. doi:10.1038/nphoton.2016.200. ISSN 1749-4885. PMC 5089541. PMID 27818707.
  15. Manley, Suliana; Gillette, Jennifer M; Patterson, George H; Shroff, Hari; Hess, Harald F; Betzig, Eric; Lippincott-Schwartz, Jennifer (2008-01-13). "High-density mapping of single-molecule trajectories with photoactivated localization microscopy". Nature Methods. 5 (2): 155–157. doi:10.1038/nmeth.1176. ISSN 1548-7091. PMID 18193054. S2CID 1101468.
  16. Lukinavičius, Gražvydas; Umezawa, Keitaro; Olivier, Nicolas; Honigmann, Alf; Yang, Guoying; Plass, Tilman; Mueller, Veronika; Reymond, Luc; Corrêa Jr, Ivan R.; Luo, Zhen-Ge; Schultz, Carsten (2013-01-06). "A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins". Nature Chemistry. 5 (2): 132–139. Bibcode:2013NatCh...5..132L. doi:10.1038/nchem.1546. hdl:11858/00-001M-0000-000E-BB40-E. ISSN 1755-4330. PMID 23344448.
  17. Sage, Daniel; Kirshner, Hagai; Pengo, Thomas; Stuurman, Nico; Min, Junhong; Manley, Suliana; Unser, Michael (2015-06-15). "Quantitative evaluation of software packages for single-molecule localization microscopy". Nature Methods. 12 (8): 717–724. doi:10.1038/nmeth.3442. ISSN 1548-7091. PMID 26076424. S2CID 11781779.
  18. Archetti, Anna; Glushkov, Evgenii; Sieben, Christian; Stroganov, Anton; Radenovic, Aleksandra; Manley, Suliana (2019-03-19). "Waveguide-PAINT offers an open platform for large field-of-view super-resolution imaging". Nature Communications. 10 (1): 1267. Bibcode:2019NatCo..10.1267A. doi:10.1038/s41467-019-09247-1. ISSN 2041-1723. PMC 6427008. PMID 30894525.
  19. Goujon, Antoine; Colom, Adai; Straková, Karolína; Mercier, Vincent; Mahecic, Dora; Manley, Suliana; Sakai, Naomi; Roux, Aurélien; Matile, Stefan (2019-02-27). "Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes". Journal of the American Chemical Society. 141 (8): 3380–3384. doi:10.1021/jacs.8b13189. ISSN 0002-7863. PMID 30744381. S2CID 73419245.
  20. Kleele, Tatjana; Rey, Timo; Winter, Julius; Zaganelli, Sofia; Mahecic, Dora; Perreten Lambert, Hélène; Ruberto, Francesco Paolo; Nemir, Mohamed; Wai, Timothy; Pedrazzini, Thierry; Manley, Suliana (May 2021). "Distinct fission signatures predict mitochondrial degradation or biogenesis". Nature. 593 (7859): 435–439. Bibcode:2021Natur.593..435K. doi:10.1038/s41586-021-03510-6. ISSN 1476-4687. PMID 33953403. S2CID 233867754.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.