PACSIN1

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.[5][6]

PACSIN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPACSIN1, SDPI, protein kinase C and casein kinase substrate in neurons 1
External IDsOMIM: 606512 MGI: 1345181 HomoloGene: 22674 GeneCards: PACSIN1
Orthologs
SpeciesHumanMouse
Entrez

29993

23969

Ensembl

ENSG00000124507

ENSMUSG00000040276

UniProt

Q9BY11

Q61644

RefSeq (mRNA)

NM_001199583
NM_020804

NM_001286743
NM_001286744
NM_011861
NM_178365

RefSeq (protein)

NP_001186512
NP_065855

NP_001273672
NP_001273673
NP_035991
NP_848142

Location (UCSC)Chr 6: 34.47 – 34.54 MbChr 17: 27.87 – 27.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

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Please see the scientific literature on Syndapin I in the PubMED database of scientific literature.

Interactions

PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I) - a scientific more useful and more widely used name than PACSIN1.

  • DNM1 >Qualmann et al., 1999</ref>

Subsequently, a variety of further interactions have been published (see PubMED database and search for syndapin I).

References

  1. GRCh38: Ensembl release 89: ENSG00000124507 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040276 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
  6. "Entrez Gene: PACSIN1 protein kinase C and casein kinase substrate in neurons 1".
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)

Further reading


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