Syndecan-2

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.[5]

SDC2
Identifiers
AliasesSDC2, CD362, HSPG, HSPG1, SYND2, syndecan 2
External IDsOMIM: 142460 MGI: 1349165 HomoloGene: 2253 GeneCards: SDC2
Orthologs
SpeciesHumanMouse
Entrez

6383

15529

Ensembl

ENSG00000169439

ENSMUSG00000022261

UniProt

P34741

P43407

RefSeq (mRNA)

NM_002998

NM_008304

RefSeq (protein)

NP_002989

NP_032330

Location (UCSC)Chr 8: 96.49 – 96.61 MbChr 15: 32.92 – 33.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.[6]

Interactions

SDC2 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000169439 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022261 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. David G, Bai XM, Van der Schueren B, Marynen P, Cassiman JJ, Van den Berghe H (June 1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development. 119 (3): 841–54. doi:10.1242/dev.119.3.841. PMID 8187643.
  6. "Entrez Gene: SDC2 syndecan 2".
  7. Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536. S2CID 2317354.
  8. Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (July 1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.
  9. Utani A, Nomizu M, Matsuura H, Kato K, Kobayashi T, Takeda U, Aota S, Nielsen PK, Shinkai H (August 2001). "A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4". J. Biol. Chem. 276 (31): 28779–88. doi:10.1074/jbc.M101420200. PMID 11373281.
  10. Granés F, Urena JM, Rocamora N, Vilaró S (April 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell Sci. 113 ( Pt 7) (7): 1267–76. doi:10.1242/jcs.113.7.1267. PMID 10704377.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.