TACC3

Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene.[5][6]

TACC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTACC3, ERIC-1, ERIC1, transforming acidic coiled-coil containing protein 3, Tacc4, maskin
External IDsOMIM: 605303 MGI: 1341163 HomoloGene: 81618 GeneCards: TACC3
Orthologs
SpeciesHumanMouse
Entrez

10460

21335

Ensembl

ENSG00000013810

ENSMUSG00000037313

UniProt

Q9Y6A5

Q9JJ11

RefSeq (mRNA)

NM_006342

NM_001040435
NM_011524
NM_001310541

RefSeq (protein)

NP_006333

n/a

Location (UCSC)Chr 4: 1.71 – 1.75 MbChr 5: 33.66 – 33.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000013810 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037313 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP (Oct 2007). "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival". J Biol Chem. 282 (40): 29273–83. doi:10.1074/jbc.M704151200. PMID 17675670.
  6. "Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.