Transgelin

Transgelin is a protein that in humans is encoded by the TAGLN gene.[5][6][7]

TAGLN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha
External IDsOMIM: 600818 MGI: 106012 HomoloGene: 2398 GeneCards: TAGLN
Orthologs
SpeciesHumanMouse
Entrez

6876

21345

Ensembl

ENSG00000149591

ENSMUSG00000032085

UniProt

Q01995

P37804

RefSeq (mRNA)

NM_003186
NM_001001522

NM_011526

RefSeq (protein)

NP_001001522
NP_003177

NP_035656

Location (UCSC)Chr 11: 117.2 – 117.21 MbChr 9: 45.84 – 45.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000149591 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032085 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kobayashi R, Kubota T, Hidaka H (Mar 1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem Biophys Res Commun. 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285.
  6. Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun. 187 (1): 1–7. doi:10.1016/S0006-291X(05)81449-4. PMID 1520290.
  7. "Entrez Gene: TAGLN transgelin".

Further reading

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