TAX1BP1

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.[5]

TAX1BP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAX1BP1, CALCOCO3, T6BP, TXBP151, Tax1 binding protein 1
External IDsOMIM: 605326 MGI: 1289308 HomoloGene: 4395 GeneCards: TAX1BP1
Orthologs
SpeciesHumanMouse
Entrez

8887

52440

Ensembl

ENSG00000106052

ENSMUSG00000004535

UniProt

Q86VP1

Q3UKC1

RefSeq (mRNA)

NM_025816
NM_001355595
NM_001355596

RefSeq (protein)

NP_080092
NP_001342524
NP_001342525

Location (UCSC)Chr 7: 27.74 – 27.84 MbChr 6: 52.69 – 52.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

TAX1BP1 has been shown to interact with TNFAIP3[6] and TRAF6.[7] TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation.

References

  1. GRCh38: Ensembl release 89: ENSG00000106052 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004535 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1".
  6. De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. PMID 10435631.
  7. Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi:10.1073/pnas.170279097. PMC 16905. PMID 10920205.

Further reading


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