TBC1D1

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.[5][6]

TBC1D1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTBC1D1, TBC, TBC1, TBC1 domain family member 1
External IDsOMIM: 609850 MGI: 1889508 HomoloGene: 56856 GeneCards: TBC1D1
Orthologs
SpeciesHumanMouse
Entrez

23216

57915

Ensembl

ENSG00000065882

ENSMUSG00000029174

UniProt

Q86TI0

Q60949

RefSeq (mRNA)

NM_001289514
NM_019636
NM_001310611

RefSeq (protein)

NP_001240841
NP_001240842
NP_001240843
NP_001240844
NP_055988

NP_001276443
NP_001297540
NP_062610

Location (UCSC)Chr 4: 37.89 – 38.14 MbChr 5: 64.31 – 64.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and cell differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000).[supplied by OMIM][6]

References

  1. GRCh38: Ensembl release 89: ENSG00000065882 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029174 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. White RA, Pasztor LM, Richardson PM, Zon LI (Sep 2000). "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4". Cytogenet Cell Genet. 89 (3–4): 272–5. doi:10.1159/000015632. PMID 10965142. S2CID 22255963.
  6. "Entrez Gene: TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1".

Further reading


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