TCF20

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene.[5][6][7]

TCF20
Identifiers
AliasesTCF20, AR1, SPBP, TCF-20, transcription factor 20 (AR1), transcription factor 20, DDVIBA
External IDsOMIM: 603107 MGI: 108399 HomoloGene: 4131 GeneCards: TCF20
Orthologs
SpeciesHumanMouse
Entrez

6942

21411

Ensembl

ENSMUSG00000041852

UniProt

Q9UGU0

Q9EPQ8

RefSeq (mRNA)

NM_005650
NM_181492
NM_001378418

NM_001114140
NM_013836

RefSeq (protein)

NP_005641
NP_852469
NP_001365347

NP_001107612
NP_038864
NP_001389767

Location (UCSC)Chr 22: 42.16 – 42.34 MbChr 15: 82.69 – 82.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.[7]

Interactions

TCF20 has been shown to interact with RNF4.[8]

References

  1. ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 GRCh38: Ensembl release 89: ENSG00000283681, ENSG00000281897, ENSG00000262024, ENSG00000282892, ENSG00000283026, ENSG00000280467, ENSG00000100207, ENSG00000276461 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041852 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rajadhyaksha A, Rivière M, Van Vooren P, Szpirer J, Szpirer C, Babin J, Bina M (October 1998). "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization". Cytogenetics and Cell Genetics. 81 (3–4): 176–7. doi:10.1159/000015021. PMID 9730594. S2CID 46832690.
  6. Rekdal C, Sjøttem E, Johansen T (December 2000). "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators". The Journal of Biological Chemistry. 275 (51): 40288–300. doi:10.1074/jbc.M006978200. PMID 10995766.
  7. "Entrez Gene: TCF20 transcription factor 20 (AR1)".
  8. Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi:10.1074/jbc.M003405200. PMID 10849425.

Further reading


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