TCL1A

TCL1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JSG
Identifiers
Aliases	TCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
External IDs	OMIM: 186960 MGI: 1097166 HomoloGene: 7565 GeneCards: TCL1A
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	95,714,196 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	105,189,052 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; lymph node; ; appendix; ; spleen; ; blood; ; bone marrow; ; bone marrow cells; ; superficial temporal artery; ; cancellous bone;
	Top expressed in
	secondary oocyte; ; morula; ; blastocyst; ; ovary; ; skin of abdomen; ; testicle; ; spleen; ; proximal tubule; ; thymus; ; seminiferous tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; identical protein binding; protein serine/threonine kinase activator activity;
Cellular component	cytoplasm; endoplasmic reticulum; intracellular membrane-bounded organelle; nucleus; protein-containing complex;
Biological process	multicellular organism development; positive regulation of cell population proliferation; positive regulation of mitochondrial membrane potential; positive regulation of protein oligomerization; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptotic process; protein homotrimerization; cellular response to tumor necrosis factor; positive regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8115
	21432
	ENSG00000100721
	ENSMUSG00000041359
	P56279
	P56280
	NM_001098725; NM_021966
	NM_001289468; NM_009337; NM_001309484; NM_001309485
	NP_001092195; NP_068801; NP_001092195.1; NP_068801.1
	NP_001276397; NP_001296413; NP_001296414; NP_033363
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[5][6][7]

Interactions

TCL1A has been shown to interact with AKT1[8][9][10] and AKT2.[8][9]

References

GRCh38: Ensembl release 89: ENSG00000100721 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041359 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
"Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".
Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis". Hematol. Oncol. Clin. North Am. 18 (4): 863–79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.
Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt". FASEB J. 21 (10): 2273–84. doi:10.1096/fj.06-7684com. PMID 17360849. S2CID 16946256.
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM (1995). "Characterization and localization of the TCL-1 oncogene product". Cancer Res. 54 (24): 6297–301. PMID 7987816.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure. 6 (2): 147–55. doi:10.1016/S0969-2126(98)00017-3. PMID 9519406.
Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712–8. doi:10.1111/j.1349-7006.1998.tb03275.x. PMC 5921886. PMID 9738977.
Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949–51. Bibcode:1999PNAS...96.2949P. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617.
Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.
Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression". Cancer Genet. Cytogenet. 135 (2): 110–9. doi:10.1016/S0165-4608(01)00655-0. PMID 12127395.
Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392–7. Bibcode:2002PNAS...9914392H. doi:10.1073/pnas.212410199. PMC 137894. PMID 12381789.
French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA (2003). "Sp1 transactivation of the TCL1 oncogene". J. Biol. Chem. 278 (2): 948–55. doi:10.1074/jbc.M207166200. PMID 12421830.
Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin". Blood. 101 (12): 5007–9. doi:10.1182/blood-2002-10-3297. PMID 12576313.
Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813–8. Bibcode:2003PNAS..100.4813K. doi:10.1073/pnas.0730710100. PMC 153638. PMID 12672960.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100721 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041359 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2783489-5] Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.

[pmid7809072-6] Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.

[entrez-7] "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".

[pmid11707444-8] Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.

[pmid10983986-9] Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.

[pmid12009899-10] French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

TCL1A

Interactions

References

Further reading