TDR Targets

The TDR Targets database is a bioinformatics project that seeks to exploit the availability of diverse genomic and chemical datasets to facilitate the identification and prioritization of drugs and drug targets in neglected disease pathogens.[2] TDR in the name of the database stands from the popular abbreviation for a special programme within the World Health Organization, whose focus is Tropical Disease Research. The project was jumpstarted by funds from this programme (see Special Programme for Research and Training in Tropical Diseases), and the initial focus of the resource was on organisms/diseases of high priority for this Programme.

TDR Targets
Content
DescriptionChemogenomics resource for neglected diseases
Data types
captured		Genomics, Medicinal Chemistry
OrganismsHuman Pathogens that cause Neglected Tropical Diseases (NTDs): Plasmodium, Trypanosoma, Leishmania, Mycobacterium, Chlamydia, Treponema, Wolbachia endosymbionts, Giardia, Entamoeba, Trichomonas, Schistosoma, Echinococcus, Onchocerca, Brugia, Loa_loa,
Contact
Research centerUNSAM, CONICET
LaboratoryArgentina Trypanosomatics Laboratory, UNSAM
AuthorsFernán Agüero, Lionel Urán Landaburu, Santiago Carmona, María Paula Magariños, Ariel J Berenstein, Santiago Videla, Ariel Chernomoretz, Parag Maru, Dhanasekaran Shanmugam (current). Gregory Crowther, Matt Berriman, Stuart Ralph, David Roos, Wes Van Voorhis (past).
Primary citationUrán Landaburu L et al. (2019) [1]
Release date2007
Access
Websitehttps://tdrtargets.org
Tools
WebPerl MVC (Catalyst_(software), DBIx::Class)
Miscellaneous
VersioningTDR Targets 6
Data release
frequency		18 months
Version6
Curation policyyes

The database functions both as a website, where researchers can look for information on targets or compounds of interest, or as a tool for prioritization of targets in whole genomes.[3] When prioritizing genes, individual database queries are used to specify one or more desirable or undesirable criteria. The output of each query will be a set of genes (e.g. all genes that produce a lethal phenotype upon a genetic knockout); and different combinations of gene sets can be obtained using standard set operators (Union, Intersection, Subtraction), including the possibility of weighting genes present in more than one set (this is particularly useful when calculating Unions). A number of prioritizations obtained with this tool have been published,[4] demonstrating a number of use cases.

The database currently hosts information for 21 bacterial and eukaryotic pathogens, and for > 2 million bioactive compounds. Information integrated into the TDR Targets database comes from disparate data sources, and therefore cannot be considered a primary data repository.

The database has seen 6 major releases since its launch in 2007, which coincided with expansion of phylogenetic coverage (e.g. inclusion of helminth genomes in release 2), incorporation of new functionalities (e.g. chemical similarity and substructure searches in release 4), major data updates to keep the database in sync with upstream data providers (in release 5), and the incorporation of a multilayer network model [5] to guide Drug_repositioning through nice user-friendly visualizations (in release 6).

See also

ChEMBL

References
  1. Urán Landaburu, Lionel; Berenstein, Ariel J.; Videla, Santiago; Maru, Parag; Shanmugam, Dhanasekaran; Chernomoretz, Ariel; Agüero, Fernán (2019). "TDR Targets 6: Driving drug discovery for human pathogens through intensive chemogenomic data integration". Nucleic Acids Research. 48 (D1): D992–D1005. doi:10.1093/nar/gkz999. PMC 7145610. PMID 31680154.
  2. "TDR Targets website (https://tdrtargets.org)".
  3. Agüero, Fernán; Al-Lazikani, Bissan; Aslett, Martin; Berriman, Matthew; Buckner, Frederick S.; Campbell, Robert K.; Carmona, Santiago; Carruthers, Ian M.; Chan, A. W. Edith; Chen, Feng; Crowther, Gregory J.; Doyle, Maria A.; Hertz-Fowler, Christiane; Hopkins, Andrew L.; McAllister, Gregg; Nwaka, Solomon; Overington, John P.; Pain, Arnab; Paolini, Gaia V.; Pieper, Ursula; Ralph, Stuart A.; Riechers, Aaron; Roos, David S.; Sali, Andrej; Shanmugam, Dhanasekaran; Suzuki, Takashi; Van Voorhis, Wesley C.; Verlinde, Christophe L. M. J. (2008). "Genomic-scale prioritization of drug targets: The TDR Targets database". Nature Reviews Drug Discovery. 7 (11): 900–907. doi:10.1038/nrd2684. PMC 3184002. PMID 18927591.
  4. Crowther, Gregory J.; Shanmugam, Dhanasekaran; Carmona, Santiago J.; Doyle, Maria A.; Hertz-Fowler, Christiane; Berriman, Matthew; Nwaka, Solomon; Ralph, Stuart A.; Roos, David S.; Van Voorhis, Wesley C.; Agüero, Fernán (2010). "Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an in Silico Approach". PLOS Neglected Tropical Diseases. 4 (8): e804. doi:10.1371/journal.pntd.0000804. PMC 2927427. PMID 20808766.
  5. Berenstein, Ariel José; Magariños, María Paula; Chernomoretz, Ariel; Agüero, Fernán (2016). "A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases". PLOS Neglected Tropical Diseases. 10 (1): e0004300. doi:10.1371/journal.pntd.0004300. PMC 4703370. PMID 26735851.


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