TEP1

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.[5][6]

TEP1
Identifiers
AliasesTEP1, TLP1, TP1, TROVE1, VAULT2, p240, telomerase associated protein 1
External IDsOMIM: 601686 MGI: 109573 HomoloGene: 5157 GeneCards: TEP1
Orthologs
SpeciesHumanMouse
Entrez

7011

21745

Ensembl

ENSG00000129566

ENSMUSG00000006281

UniProt

Q99973

P97499

RefSeq (mRNA)

NM_007110
NM_001319035

NM_009351

RefSeq (protein)

NP_001305964
NP_009041

NP_033377

Location (UCSC)Chr 14: 20.37 – 20.41 MbChr 14: 51.06 – 51.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.[6] It is also a minor vault protein.

References

  1. GRCh38: Ensembl release 89: ENSG00000129566 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006281 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (November 1997). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.
  6. "Entrez Gene: TEP1 telomerase-associated protein 1".

Further reading


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