TGIF2

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.[5][6]

TGIF2
Identifiers
AliasesTGIF2, TGFB induced factor homeobox 2
External IDsOMIM: 607294 MGI: 1915299 HomoloGene: 32514 GeneCards: TGIF2
Orthologs
SpeciesHumanMouse
Entrez

60436

228839

Ensembl

ENSG00000118707

ENSMUSG00000062175

UniProt

Q9GZN2

Q8C0Y1

RefSeq (mRNA)

NM_021809
NM_001199513
NM_001199514
NM_001199515

NM_001291124
NM_173396

RefSeq (protein)

NP_001186442
NP_001186443
NP_001186444
NP_068581

NP_001278053
NP_775572

Location (UCSC)Chr 20: 36.57 – 36.59 MbChr 2: 156.68 – 156.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000118707 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062175 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Imoto I, Pimkhaokham A, Watanabe T, Saito-Ohara F, Soeda E, Inazawa J (Oct 2000). "Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines". Biochem Biophys Res Commun. 276 (1): 264–70. doi:10.1006/bbrc.2000.3449. PMID 11006116.
  6. "Entrez Gene: TGIF2 TGFB-induced factor homeobox 2".

Further reading


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