Thrombospondin 4

THBS4
Identifiers
Aliases	THBS4, TSP4, TSP-4, thrombospondin 4
External IDs	OMIM: 600715 MGI: 1101779 HomoloGene: 20691 GeneCards: THBS4
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	80,083,287 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	92,931,326 bp[2]
RNA expression pattern
	Top expressed in
	Achilles tendon; ; synovial joint; ; pericardium; ; synovial membrane; ; tibial nerve; ; body of tongue; ; vena cava; ; secondary oocyte; ; urethra; ; triceps brachii muscle;
	Top expressed in
	ankle; ; left colon; ; sciatic nerve; ; lip; ; body of femur; ; soleus muscle; ; intercostal muscle; ; tibialis anterior muscle; ; quadriceps femoris muscle; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; integrin binding; protein binding; growth factor activity; calcium ion binding;
Cellular component	basement membrane; extracellular exosome; extracellular region; sarcoplasmic reticulum; extracellular matrix; endoplasmic reticulum; extracellular space; collagen-containing extracellular matrix;
Biological process	myoblast migration; positive regulation of endothelial cell proliferation; endothelial cell-cell adhesion; response to unfolded protein; cell adhesion; positive regulation of neutrophil chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of angiogenesis; tissue remodeling; positive regulation of cell division; response to endoplasmic reticulum stress; regulation of tissue remodeling; behavioral response to pain; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7060
	21828
	ENSG00000113296
	ENSMUSG00000021702
	P35443
	Q9Z1T2
	NM_001306212; NM_001306213; NM_001306214; NM_003248
	NM_011582
	NP_001293141; NP_001293142; NP_001293143; NP_003239
	NP_035712
	Wikidata
View/Edit Human	View/Edit Mouse

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.[5][6]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. This protein may be involved in local signaling in the developing and adult nervous system, in bone formation and fracture healing, and in osteoarthritis.[6]

References

GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. doi:10.1074/jbc.270.6.2809. PMID 7852353.
"Entrez Gene: THBS4 thrombospondin 4".

Arber S, Caroni P (1996). "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth". J. Cell Biol. 131 (4): 1083–94. doi:10.1083/jcb.131.4.1083. PMC 2200004. PMID 7490284.
Lawler J, Duquette M, Urry L, et al. (1993). "The evolution of the thrombospondin gene family". J. Mol. Evol. 36 (6): 509–16. Bibcode:1993JMolE..36..509L. doi:10.1007/BF00556355. PMID 8350346. S2CID 22473680.
Lawler J, Duquette M, Whittaker CA, et al. (1993). "Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family". J. Cell Biol. 120 (4): 1059–67. doi:10.1083/jcb.120.4.1059. PMC 2200072. PMID 8432726.
Newton G, Weremowicz S, Morton CC, et al. (2000). "The thrombospondin-4 gene". Mamm. Genome. 10 (10): 1010–6. doi:10.1007/s003359901149. PMID 10501972. S2CID 27379216.
Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID 11137453.
Luo J, Dunn T, Ewing C, et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953. S2CID 42730702.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Congote LF, Difalco MR, Gibbs BF (2004). "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation". Biochem. Biophys. Res. Commun. 324 (2): 673–8. doi:10.1016/j.bbrc.2004.09.107. PMID 15474480.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. doi:10.1200/JCO.2005.11.353. PMID 15897551.
Stenina OI, Ustinov V, Krukovets I, et al. (2006). "Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites". FASEB J. 19 (13): 1893–5. doi:10.1096/fj.05-3712fje. PMID 16148025. S2CID 27097671.
Misenheimer TM, Mosher DF (2006). "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2". J. Biol. Chem. 280 (50): 41229–35. doi:10.1074/jbc.M504696200. PMC 2219889. PMID 16246837.
Cui J, Randell E, Renouf J, et al. (2006). "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population". Am. Heart J. 152 (3): 543.e1–5. doi:10.1016/j.ahj.2006.06.002. PMID 16923428.
Cáceres M, Suwyn C, Maddox M, et al. (2007). "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution". Cereb. Cortex. 17 (10): 2312–21. doi:10.1093/cercor/bhl140. PMID 17182969.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7852353-5] Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. doi:10.1074/jbc.270.6.2809. PMID 7852353.

[entrez-6] "Entrez Gene: THBS4 thrombospondin 4".

Thrombospondin 4

References

Further reading