TM5441

TM5441
Clinical data
ATC code	None;
Identifiers
	IUPAC name 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid;
CAS Number	1190221-43-2;
PubChem CID	44250349;
ChemSpider	60598824;
ChEMBL	ChEMBL4204253;
Chemical and physical data
Formula	C21H17ClN2O6
Molar mass	428.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC(=C1)NC(=O)COCC(=O)NC2=C(C=C(C=C2)Cl)C(=O)O)C3=COC=C3;
	InChI InChI=1S/C21H17ClN2O6/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28); Key:BGGMLMAPVODXAU-UHFFFAOYSA-N;

TM5441 is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1). By inhibiting PAI-1, it increases activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade. It has been researched for conditions such as hepatic steatosis and diabetic nephropathy, and while it has not been developed for medical use, it is widely used in scientific research.[1][2][3][4]

References

Jeong BY, Uddin MJ, Park JH, Lee JH, Lee HB, Miyata T, Ha H (2016). "Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model". PLOS ONE. 11 (6): e0157012. Bibcode:2016PLoSO..1157012J. doi:10.1371/journal.pone.0157012. PMID 27258009.
Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE (September 2017). "PAI-1 is a critical regulator of FGF23 homeostasis". Science Advances. 3 (9): e1603259. Bibcode:2017SciA....3E3259E. doi:10.1126/sciadv.1603259. PMID 28924605. S2CID 13059562.
Hosaka S, Yamada T, Takahashi K, Dan T, Kaneko K, Kodama S, et al. (2020). "Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance". Frontiers in Pharmacology. 11: 943. doi:10.3389/fphar.2020.00943. PMID 32670063.
Kuru Bektaşoğlu P, Koyuncuoğlu T, Akbulut S, Akakın D, Eyüboğlu İP, Erzik C, et al. (December 2021). "Neuroprotective Effect of Plasminogen Activator Inhibitor-1 Antagonist in the Rat Model of Mild Traumatic Brain Injury". Inflammation. 44 (6): 2499–2517. doi:10.1007/s10753-021-01520-0. PMID 34460025. S2CID 236584848.

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