TMBIM4

Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4 gene.[5][6][7] It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.

TMBIM4
Identifiers
AliasesTMBIM4, GAAP, LFG4, S1R, ZPRO, CGI-119, transmembrane BAX inhibitor motif containing 4
External IDsOMIM: 616874 MGI: 1915462 HomoloGene: 56740 GeneCards: TMBIM4
Orthologs
SpeciesHumanMouse
Entrez

51643

68212

Ensembl

ENSG00000155957

ENSMUSG00000020225

UniProt

Q9HC24

Q9DA39

RefSeq (mRNA)

NM_016056
NM_001282606
NM_001282609
NM_001282610

NM_026617

RefSeq (protein)

NP_001269535
NP_001269538
NP_001269539
NP_057140
NP_001269535.1

NP_080893

Location (UCSC)Chr 12: 66.14 – 66.17 MbChr 10: 120.04 – 120.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Human GAAP [8] is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of GAAP can help prevent apoptosis.[9][10] GAAP is also involved in promoting cell migration[11] [12] and has been identified as a novel Golgi cation channel.[13] Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.

See also

  • Golgi
  • Apoptosis
  • Ion channel
  • Cell migration

References

  1. GRCh38: Ensembl release 89: ENSG00000155957 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020225 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. "Entrez Gene: TMBIM4 transmembrane BAX inhibitor motif containing 4".
  8. Saraiva, Nuno; Carrara, Guia; Smith, Geoffrey L (2017). "Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer". Open Biology. 7(5):170045. (5): 170045. doi:10.1098/rsob.170045. PMC 5451544. PMID 28469007.
  9. de Mattia F, Gubser C, van Dommelen MM, Visch HJ, Distelmaier F, Postigo A, Luyten T, Parys JB, de Smedt H, Smith GL, Willems PH, van Kuppeveld FJ (August 2009). "Human Golgi antiapoptotic protein modulates intracellular calcium fluxes". Molecular Biology of the Cell. 20 (16): 3638–45. doi:10.1091/mbc.E09-05-0385. PMC 2777924. PMID 19553469.
  10. Saraiva N, Prole DL, Carrara G, Maluquer de Motes C, Johnson BF, Byrne B, Taylor CW, Smith GL (May 2013). "Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium". The Journal of Biological Chemistry. 288 (18): 13057–67. doi:10.1074/jbc.M112.414367. PMC 3642348. PMID 23508950.
  11. Saraiva, Nuno; Prole, David L.; Carrara, Guia; Johnson, Benjamin F.; Taylor, Colin W.; Parsons, Maddy; Smith, Geoffrey L. (2013-08-19). "hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2". J Cell Biol. 202 (4): 699–713. doi:10.1083/jcb.201301016. ISSN 0021-9525. PMC 3747308. PMID 23940116.
  12. Almeida, Nuno; Saraiva, Nuno (2020). "Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism". Redox Biology. 28:101361: 101361. doi:10.1016/j.redox.2019.101361. PMC 6838802. PMID 31693977.
  13. Carrara, Guia; Saraiva, Nuno; Parsons, Maddy; Byrne, Bernadette; Prole, David L.; Taylor, Colin W.; Smith, Geoffrey L. (2015-05-01). "Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration". Journal of Biological Chemistry. 290 (18): 11785–11801. doi:10.1074/jbc.M115.637306. ISSN 0021-9258. PMC 4416878. PMID 25713081.

Further reading


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