TMEM165

Transmembrane protein 165 is a protein that in humans is encoded by the TMEM165 gene.[5]

TMEM165
Identifiers
AliasesTMEM165, CDG2K, FT27, GDT1, TMPT27, TPARL, transmembrane protein 165, SLC64A1
External IDsOMIM: 614726 MGI: 894407 HomoloGene: 5411 GeneCards: TMEM165
Orthologs
SpeciesHumanMouse
Entrez

55858

21982

Ensembl

ENSG00000134851

ENSMUSG00000029234

UniProt

Q9HC07

P52875

RefSeq (mRNA)

NM_018475

NM_011626

RefSeq (protein)

NP_060945

NP_035756

Location (UCSC)Chr 4: 55.4 – 55.45 MbChr 5: 76.33 – 76.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of TMEM165 function. A conditional knockout mouse line, called Tmem165tm1e(EUCOMM)Wtsi[11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][15] Twenty three tests were carried out on mutant mice and two significant abnormalities were observed.[9] Homozygous mutant males had skeletal deformities, including scoliosis, and an increased susceptibility to bacterial infection.[9]

References
  1. GRCh38: Ensembl release 89: ENSG00000134851 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029234 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Transmembrane protein 165". Retrieved 2011-12-06.
  6. "Radiography data for Tmem165". Wellcome Trust Sanger Institute.
  7. "Salmonella infection data for Tmem165". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Tmem165". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  15. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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