TMEM66

SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66 (transmembrane protein 66).[5][6]

SARAF
Identifiers
AliasesSARAF, FOAP-7, TMEM66, XTP3, HSPC035, store-operated calcium entry associated regulatory factor
External IDsOMIM: 614768 MGI: 1915137 HomoloGene: 9398 GeneCards: SARAF
Orthologs
SpeciesHumanMouse
Entrez

51669

67887

Ensembl

ENSG00000133872

ENSMUSG00000031532

UniProt

Q96BY9

Q8R3Q0

RefSeq (mRNA)

NM_016127
NM_001284239

NM_026432

RefSeq (protein)

NP_001271168
NP_057211

NP_080708

Location (UCSC)Chr 8: 30.06 – 30.08 MbChr 8: 34.62 – 34.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000133872 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031532 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. "Entrez Gene: SARAF store-operated calcium entry-associated regulatory factor".
  7. Palty R, Raveh A, Kaminsky I, Meller R, Reuveny E (2012). "SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling". Cell. 149 (2): 425–38. doi:10.1016/j.cell.2012.01.055. PMID 22464749.

Further reading


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