TMIGD2

TMIGD2
Identifiers
Aliases	TMIGD2, IGPR-1, IGPR1, CD28H, transmembrane and immunoglobulin domain containing 2
External IDs	OMIM: 614715 HomoloGene: 89154 GeneCards: TMIGD2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	4,302,431 bp[1]
RNA expression pattern
	Top expressed in
	vena cava; ; cerebellar vermis; ; thymus; ; superficial temporal artery; ; cardia; ; body of tongue; ; pylorus; ; ventral tegmental area; ; inferior ganglion of vagus nerve; ; subthalamic nucleus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; coreceptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; extracellular space;
Biological process	T cell costimulation; immune response; positive regulation of cytokine production; immunoglobulin production; positive regulation of activated T cell proliferation; positive regulation of angiogenesis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	126259
	n/a
	ENSG00000167664
	n/a
	Q96BF3
	n/a
	NM_001169126; NM_001308232; NM_144615; NM_001395549
	n/a
	NP_001162597; NP_001295161; NP_653216
	n/a
	Wikidata
View/Edit Human

Transmembrane and immunoglobulin domain containing 2 is a protein that in humans is encoded by the TMIGD2 gene.[3][4][5][6] TMIGD2 was discovered by Nader Rahimi.[7][8][9]

References

GRCh38: Ensembl release 89: ENSG00000167664 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Gene: TMIGD2". Ensembl Project.
"TMIG2_HUMAN". UniProt.
"TMIGD2". GeneCards.
"Cell Atlas: TMIGD2". The Human Protein Atlas.
Woolf N, Pearson BE, Bondzie PA, Meyer RD, Lavaei M, Belkina AC, et al. (September 2017). "Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy". Oncogenesis. 6 (9): e378. doi:10.1038/oncsis.2017.77. PMC 5623903. PMID 28920928.
Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, et al. (December 2016). "IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function". Journal of Molecular Biology. 428 (24 Pt B): 5019–5033. doi:10.1016/j.jmb.2016.11.003. PMC 5138093. PMID 27838321.
Rahimi N, Rezazadeh K, Mahoney JE, Hartsough E, Meyer RD (May 2012). "Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis". Molecular Biology of the Cell. 23 (9): 1646–56. doi:10.1091/mbc.E11-11-0934. PMC 3338432. PMID 22419821.

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