TNFAIP1

TNFAIP1
Identifiers
Aliases	TNFAIP1, B12, B61, BTBD34, EDP1, hBACURD2, TNF alpha induced protein 1
External IDs	OMIM: 191161 MGI: 104961 HomoloGene: 22519 GeneCards: TNFAIP1
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	28,347,009 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	78,427,158 bp[2]
RNA expression pattern
	Top expressed in
	hair follicle; ; spleen; ; upper lobe of left lung; ; left ventricle; ; right lobe of liver; ; gallbladder; ; right lung; ; islet of Langerhans; ; body of pancreas; ; smooth muscle tissue;
	Top expressed in
	Paneth cell; ; endocardial cushion; ; fossa; ; condyle; ; ciliary body; ; medullary collecting duct; ; retinal pigment epithelium; ; internal carotid artery; ; external carotid artery; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; protein domain specific binding; identical protein binding;
Cellular component	cytoplasm; endosome; Cul3-RING ubiquitin ligase complex; nucleolus; nucleus;
Biological process	positive regulation of DNA replication; DNA replication; negative regulation of Rho protein signal transduction; protein homooligomerization; cell migration; protein ubiquitination; immune response; stress fiber assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	7126
	21927
	ENSG00000109079
	ENSMUSG00000017615
	Q13829
	O70479
	NM_021137
	NM_001159392; NM_009395
	NP_066960
	NP_001152864; NP_033421
	Wikidata
View/Edit Human	View/Edit Mouse

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene.[5][6][7]

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.[7]

References

GRCh38: Ensembl release 89: ENSG00000109079 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000017615 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM (Mar 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J Biol Chem. 265 (5): 2973–8. doi:10.1016/S0021-9258(19)39896-5. PMID 2406243.
Holzman LB, Marks RM, Dixit VM (Dec 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Mol Cell Biol. 10 (11): 5830–8. doi:10.1128/MCB.10.11.5830. PMC 361366. PMID 2233719.
"Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)".

Wolf FW, Marks RM, Sarma V, et al. (1992). "Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene". J. Biol. Chem. 267 (2): 1317–26. doi:10.1016/S0021-9258(18)48432-3. PMID 1370465.
Pandey A, Shao H, Marks RM, et al. (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science. 268 (5210): 567–9. Bibcode:1995Sci...268..567P. doi:10.1126/science.7536959. PMID 7536959.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Link CD, Taft A, Kapulkin V, et al. (2003). "Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model". Neurobiol. Aging. 24 (3): 397–413. doi:10.1016/S0197-4580(02)00224-5. PMID 12600716. S2CID 22679483.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109079 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017615 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2406243-5] Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM (Mar 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J Biol Chem. 265 (5): 2973–8. doi:10.1016/S0021-9258(19)39896-5. PMID 2406243.

[pmid2233719-6] Holzman LB, Marks RM, Dixit VM (Dec 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Mol Cell Biol. 10 (11): 5830–8. doi:10.1128/MCB.10.11.5830. PMC 361366. PMID 2233719.

[entrez-7] "Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)".

TNFAIP1

References

Further reading