TNFAIP8

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene.[5][6][7] It is preferentially expressed in human immune cell types.[8]

TNFAIP8
Identifiers
AliasesTNFAIP8, GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2, TNF alpha induced protein 8
External IDsOMIM: 612111 MGI: 2147191 HomoloGene: 8649 GeneCards: TNFAIP8
Orthologs
SpeciesHumanMouse
Entrez

25816

106869

Ensembl

ENSG00000145779

ENSMUSG00000062210

UniProt

O95379

Q921Z5

RefSeq (mRNA)

NM_001177759
NM_001177760
NM_134131
NM_001360935

RefSeq (protein)

NP_001171230
NP_001171231
NP_598892
NP_001347864

Location (UCSC)Chr 5: 119.27 – 119.4 MbChr 18: 50.11 – 50.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References

  1. GRCh38: Ensembl release 89: ENSG00000145779 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062210 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (Jun 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
  6. Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein". J Biol Chem. 275 (4): 2973–8. doi:10.1074/jbc.275.4.2973. PMID 10644768.
  7. "Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8".
  8. Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.