TNFAIP8

TNFAIP8
Identifiers
Aliases	TNFAIP8, GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2, TNF alpha induced protein 8
External IDs	OMIM: 612111 MGI: 2147191 HomoloGene: 8649 GeneCards: TNFAIP8
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	119,399,688 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	50,240,240 bp[2]
RNA expression pattern
	Top expressed in
	appendix; ; bone marrow; ; monocyte; ; lymph node; ; bone marrow cells; ; cancellous bone; ; palpebral conjunctiva; ; secondary oocyte; ; parietal pleura; ; blood;
	Top expressed in
	thymus; ; kidney; ; spleen; ; conjunctival fornix; ; myocardium of ventricle; ; belly cord; ; proximal tubule; ; ciliary body; ; esophagus; ; skin of abdomen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding;
Cellular component	cytoplasm; nucleoplasm;
Biological process	negative regulation of apoptotic process; apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	25816
	106869
	ENSG00000145779
	ENSMUSG00000062210
	O95379
	Q921Z5
NM_014350; NM_001077654; NM_001286813; NM_001286814; NM_001286815;
	NM_001286817
	NM_001177759; NM_001177760; NM_134131; NM_001360935
NP_001071122; NP_001273742; NP_001273743; NP_001273744; NP_001273746;
	NP_055165
	NP_001171230; NP_001171231; NP_598892; NP_001347864
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene.[5][6][7] It is preferentially expressed in human immune cell types.[8]

References

GRCh38: Ensembl release 89: ENSG00000145779 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000062210 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (Jun 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein". J Biol Chem. 275 (4): 2973–8. doi:10.1074/jbc.275.4.2973. PMID 10644768.
"Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8".
Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Kumar D, Gokhale P, Broustas C, et al. (2004). "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells". Oncogene. 23 (2): 612–6. doi:10.1038/sj.onc.1207123. PMID 14724590.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145779 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062210 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10233894-5] Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (Jun 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.

[pmid10644768-6] Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein". J Biol Chem. 275 (4): 2973–8. doi:10.1074/jbc.275.4.2973. PMID 10644768.

[entrez-7] "Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8".

[Li_et_al_2018-8] Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

TNFAIP8

References

Further reading