TOMM34

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.[5][6]

TOMM34
Identifiers
AliasesTOMM34, HTOM34P, TOM34, URCC3, translocase of outer mitochondrial membrane 34
External IDsOMIM: 616049 MGI: 1914395 HomoloGene: 4956 GeneCards: TOMM34
Orthologs
SpeciesHumanMouse
Entrez

10953

67145

Ensembl

ENSG00000025772

ENSMUSG00000018322

UniProt

Q15785

Q9CYG7

RefSeq (mRNA)

NM_006809

NM_001291155
NM_025996

RefSeq (protein)

NP_006800

NP_001278084
NP_080272

Location (UCSC)Chr 20: 44.94 – 44.96 MbChr 2: 163.9 – 163.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000025772 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018322 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (Oct 1997). "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol. 16 (9): 1067–74. doi:10.1089/dna.1997.16.1067. PMID 9324309.
  6. "Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34".

Further reading


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