TRA2A

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.[5][6][7]

TRA2A
Identifiers
AliasesTRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDsOMIM: 602718 MGI: 1933972 HomoloGene: 40866 GeneCards: TRA2A
Orthologs
SpeciesHumanMouse
Entrez

29896

101214

Ensembl

ENSG00000164548

ENSMUSG00000029817

UniProt

Q13595

Q6PFR5

RefSeq (mRNA)

NM_198102
NM_001347209
NM_001362188

RefSeq (protein)

n/a

Location (UCSC)Chr 7: 23.5 – 23.53 MbChr 6: 49.22 – 49.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000164548 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029817 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.
  6. Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
  7. "Entrez Gene: TRA2A transformer-2 alpha".

Further reading


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